mTOR and its tight regulation for iNKT cell development and effector function.
Publication
, Journal Article
Yang, W; Gorentla, B; Zhong, X-P; Shin, J
Published in: Mol Immunol
December 2015
Invariant NKT (iNKT) cells, which express the invariant Vα14Jα18 TCR that recognizes lipid antigens, have the ability to rapidly respond to agonist stimulation, producing a variety of cytokines that can shape both innate and adaptive immunity. iNKT cells have been implicated in host defense against microbial infection, in anti-tumor immunity, and a multitude of diseases such as allergies, asthma, graft versus host disease, and obesity. Emerging evidence has demonstrated crucial role for mammalian target of rapamycin (mTOR) in immune cells, including iNKT. In this review we will discuss current understanding of how mTOR and its tight regulation control iNKT cell development, effector lineage differentiation, and function.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Mol Immunol
DOI
EISSN
1872-9142
Publication Date
December 2015
Volume
68
Issue
2 Pt C
Start / End Page
536 / 545
Location
England
Related Subject Headings
- TOR Serine-Threonine Kinases
- Signal Transduction
- Natural Killer T-Cells
- Lymphocyte Activation
- Immunology
- Humans
- Cell Differentiation
- Animals
- 3204 Immunology
- 3101 Biochemistry and cell biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Yang, W., Gorentla, B., Zhong, X.-P., & Shin, J. (2015). mTOR and its tight regulation for iNKT cell development and effector function. Mol Immunol, 68(2 Pt C), 536–545. https://doi.org/10.1016/j.molimm.2015.07.022
Yang, Wei, Balachandra Gorentla, Xiao-Ping Zhong, and Jinwook Shin. “mTOR and its tight regulation for iNKT cell development and effector function.” Mol Immunol 68, no. 2 Pt C (December 2015): 536–45. https://doi.org/10.1016/j.molimm.2015.07.022.
Yang W, Gorentla B, Zhong X-P, Shin J. mTOR and its tight regulation for iNKT cell development and effector function. Mol Immunol. 2015 Dec;68(2 Pt C):536–45.
Yang, Wei, et al. “mTOR and its tight regulation for iNKT cell development and effector function.” Mol Immunol, vol. 68, no. 2 Pt C, Dec. 2015, pp. 536–45. Pubmed, doi:10.1016/j.molimm.2015.07.022.
Yang W, Gorentla B, Zhong X-P, Shin J. mTOR and its tight regulation for iNKT cell development and effector function. Mol Immunol. 2015 Dec;68(2 Pt C):536–545.
Published In
Mol Immunol
DOI
EISSN
1872-9142
Publication Date
December 2015
Volume
68
Issue
2 Pt C
Start / End Page
536 / 545
Location
England
Related Subject Headings
- TOR Serine-Threonine Kinases
- Signal Transduction
- Natural Killer T-Cells
- Lymphocyte Activation
- Immunology
- Humans
- Cell Differentiation
- Animals
- 3204 Immunology
- 3101 Biochemistry and cell biology