A roadmap for interpreting (13)C metabolite labeling patterns from cells.
Publication
, Journal Article
Buescher, JM; Antoniewicz, MR; Boros, LG; Burgess, SC; Brunengraber, H; Clish, CB; DeBerardinis, RJ; Feron, O; Frezza, C; Ghesquiere, B; Nöh, K ...
Published in: Current opinion in biotechnology
August 2015
Measuring intracellular metabolism has increasingly led to important insights in biomedical research. (13)C tracer analysis, although less information-rich than quantitative (13)C flux analysis that requires computational data integration, has been established as a time-efficient method to unravel relative pathway activities, qualitative changes in pathway contributions, and nutrient contributions. Here, we review selected key issues in interpreting (13)C metabolite labeling patterns, with the goal of drawing accurate conclusions from steady state and dynamic stable isotopic tracer experiments.
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Published In
Current opinion in biotechnology
DOI
EISSN
1879-0429
ISSN
0958-1669
Publication Date
August 2015
Volume
34
Start / End Page
189 / 201
Related Subject Headings
- Metabolic Networks and Pathways
- Isotope Labeling
- Humans
- Cell Survival
- Carbon Isotopes
- Biotechnology
- Animals
- 3206 Medical biotechnology
- 3106 Industrial biotechnology
- 3001 Agricultural biotechnology
Citation
APA
Chicago
ICMJE
MLA
NLM
Buescher, J. M., Antoniewicz, M. R., Boros, L. G., Burgess, S. C., Brunengraber, H., Clish, C. B., … Fendt, S.-M. (2015). A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current Opinion in Biotechnology, 34, 189–201. https://doi.org/10.1016/j.copbio.2015.02.003
Buescher, Joerg M., Maciek R. Antoniewicz, Laszlo G. Boros, Shawn C. Burgess, Henri Brunengraber, Clary B. Clish, Ralph J. DeBerardinis, et al. “A roadmap for interpreting (13)C metabolite labeling patterns from cells.” Current Opinion in Biotechnology 34 (August 2015): 189–201. https://doi.org/10.1016/j.copbio.2015.02.003.
Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current opinion in biotechnology. 2015 Aug;34:189–201.
Buescher, Joerg M., et al. “A roadmap for interpreting (13)C metabolite labeling patterns from cells.” Current Opinion in Biotechnology, vol. 34, Aug. 2015, pp. 189–201. Epmc, doi:10.1016/j.copbio.2015.02.003.
Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks ODK, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt S-M. A roadmap for interpreting (13)C metabolite labeling patterns from cells. Current opinion in biotechnology. 2015 Aug;34:189–201.
Published In
Current opinion in biotechnology
DOI
EISSN
1879-0429
ISSN
0958-1669
Publication Date
August 2015
Volume
34
Start / End Page
189 / 201
Related Subject Headings
- Metabolic Networks and Pathways
- Isotope Labeling
- Humans
- Cell Survival
- Carbon Isotopes
- Biotechnology
- Animals
- 3206 Medical biotechnology
- 3106 Industrial biotechnology
- 3001 Agricultural biotechnology