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PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response.

Publication ,  Journal Article
Hart, SA; Devendra, GP; Kim, YY; Flamm, SD; Kalahasti, V; Arruda, J; Walker, E; Boonyasirinant, T; Bolen, M; Setser, R; Krasuski, RA
Published in: J Cardiovasc Magn Reson
September 4, 2013

BACKGROUND: Tetralogy of Fallot (TOF) repair and pulmonary valvotomy for pulmonary stenosis (PS) lead to progressive pulmonary insufficiency (PI), right ventricular enlargement and dysfunction. This study assessed whether pulmonary regurgitant fraction measured by cardiovascular magnetic resonance (CMR) could be reduced with inhaled nitric oxide (iNO). METHODS: Patients with at least moderate PI by echocardiography undergoing clinically indicated CMR were prospectively enrolled. Patients with residual hemodynamic lesions were excluded. Ventricular volume and blood flow sequences were obtained at baseline and during administration of 40 ppm iNO. RESULTS: Sixteen patients (11 with repaired TOF and 5 with repaired PS) completed the protocol with adequate data for analysis. The median age [range] was 35 [19-46] years, BMI was 26 ± 5 kg/m(2) (mean ± SD), 50% were women and 75% were in NYHA class I. Right ventricular end diastolic volume index for the cohort was 157 ± 33 mL/m(2), end systolic volume index was 93 ± 20 mL/m(2) and right ventricular ejection fraction was 40 ± 6%. Baseline pulmonary regurgitant volume was 45 ± 25 mL/beat and regurgitant fraction was 35 ± 16%. During administration of iNO, regurgitant volume was reduced by an average of 6 ± 9% (p=0.01) and regurgitant fraction was reduced by an average of 5 ± 8% (p=0.02). No significant changes were observed in ventricular indices for either the left or right ventricle. CONCLUSION: iNO was successfully administered during CMR acquisition and appears to reduce regurgitant fraction in patients with at least moderate PI suggesting a potential role for selective pulmonary vasodilator therapy in these patients. TRIALS REGISTRATION: ClinicalTrials.gov, NCT00543933.

Duke Scholars

Published In

J Cardiovasc Magn Reson

DOI

EISSN

1532-429X

Publication Date

September 4, 2013

Volume

15

Issue

1

Start / End Page

75

Location

England

Related Subject Headings

  • Young Adult
  • Ventricular Function, Right
  • Ventricular Function, Left
  • Vasodilator Agents
  • Treatment Outcome
  • Tetralogy of Fallot
  • Stroke Volume
  • Pulmonary Valve Stenosis
  • Pulmonary Valve Insufficiency
  • Pulmonary Valve
 

Citation

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Hart, S. A., Devendra, G. P., Kim, Y. Y., Flamm, S. D., Kalahasti, V., Arruda, J., … Krasuski, R. A. (2013). PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response. J Cardiovasc Magn Reson, 15(1), 75. https://doi.org/10.1186/1532-429X-15-75
Hart, Stephen A., Ganesh P. Devendra, Yuli Y. Kim, Scott D. Flamm, Vidyasagar Kalahasti, Janine Arruda, Esteban Walker, et al. “PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response.J Cardiovasc Magn Reson 15, no. 1 (September 4, 2013): 75. https://doi.org/10.1186/1532-429X-15-75.
Hart SA, Devendra GP, Kim YY, Flamm SD, Kalahasti V, Arruda J, et al. PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response. J Cardiovasc Magn Reson. 2013 Sep 4;15(1):75.
Hart, Stephen A., et al. “PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response.J Cardiovasc Magn Reson, vol. 15, no. 1, Sept. 2013, p. 75. Pubmed, doi:10.1186/1532-429X-15-75.
Hart SA, Devendra GP, Kim YY, Flamm SD, Kalahasti V, Arruda J, Walker E, Boonyasirinant T, Bolen M, Setser R, Krasuski RA. PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response. J Cardiovasc Magn Reson. 2013 Sep 4;15(1):75.
Journal cover image

Published In

J Cardiovasc Magn Reson

DOI

EISSN

1532-429X

Publication Date

September 4, 2013

Volume

15

Issue

1

Start / End Page

75

Location

England

Related Subject Headings

  • Young Adult
  • Ventricular Function, Right
  • Ventricular Function, Left
  • Vasodilator Agents
  • Treatment Outcome
  • Tetralogy of Fallot
  • Stroke Volume
  • Pulmonary Valve Stenosis
  • Pulmonary Valve Insufficiency
  • Pulmonary Valve