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Congenital heart disease and pulmonary hypertension.

Publication ,  Journal Article
Gupta, V; Tonelli, AR; Krasuski, RA
Published in: Heart Fail Clin
July 2012

Many patients with congenital heart disease and systemic-to-pulmonary shunts develop pulmonary arterial hypertension (PAH), particularly if the cardiac defect is left unrepaired. A persistent increase in pulmonary blood flow may lead to obstructive arteriopathy and increased pulmonary vascular resistance, a condition that can lead to reversal of shunt and cyanosis (Eisenmenger syndrome). Cardiac catheterization is crucial to confirm diagnosis and facilitate treatment. Bosentan is the only medication to date to be compared with placebo in a randomized controlled trial specifically targeting congenital heart disease-associated PAH. Lung transplantation with repair of the cardiac defect or combined heart-lung transplantation is reserved for recalcitrant cases.

Duke Scholars

Published In

Heart Fail Clin

DOI

ISSN

1551-7136

Publication Date

July 2012

Volume

8

Issue

3

Start / End Page

427 / 445

Location

United States

Related Subject Headings

  • Risk Factors
  • Pulmonary Embolism
  • Oxygen Inhalation Therapy
  • Hypertension, Pulmonary
  • Humans
  • Hemoptysis
  • Heart Defects, Congenital
  • Exercise Tolerance
  • Exercise Test
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gupta, V., Tonelli, A. R., & Krasuski, R. A. (2012). Congenital heart disease and pulmonary hypertension. Heart Fail Clin, 8(3), 427–445. https://doi.org/10.1016/j.hfc.2012.04.002
Gupta, Vedant, Adriano R. Tonelli, and Richard A. Krasuski. “Congenital heart disease and pulmonary hypertension.Heart Fail Clin 8, no. 3 (July 2012): 427–45. https://doi.org/10.1016/j.hfc.2012.04.002.
Gupta V, Tonelli AR, Krasuski RA. Congenital heart disease and pulmonary hypertension. Heart Fail Clin. 2012 Jul;8(3):427–45.
Gupta, Vedant, et al. “Congenital heart disease and pulmonary hypertension.Heart Fail Clin, vol. 8, no. 3, July 2012, pp. 427–45. Pubmed, doi:10.1016/j.hfc.2012.04.002.
Gupta V, Tonelli AR, Krasuski RA. Congenital heart disease and pulmonary hypertension. Heart Fail Clin. 2012 Jul;8(3):427–445.
Journal cover image

Published In

Heart Fail Clin

DOI

ISSN

1551-7136

Publication Date

July 2012

Volume

8

Issue

3

Start / End Page

427 / 445

Location

United States

Related Subject Headings

  • Risk Factors
  • Pulmonary Embolism
  • Oxygen Inhalation Therapy
  • Hypertension, Pulmonary
  • Humans
  • Hemoptysis
  • Heart Defects, Congenital
  • Exercise Tolerance
  • Exercise Test
  • Cardiovascular System & Hematology