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How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

Publication ,  Journal Article
Yashin, AI; Arbeev, KG; Arbeeva, LS; Wu, D; Akushevich, I; Kovtun, M; Yashkin, A; Kulminski, A; Culminskaya, I; Stallard, E; Li, M; Ukraintseva, SV
Published in: Biogerontology
February 2016

Increasing proportions of elderly individuals in developed countries combined with substantial increases in related medical expenditures make the improvement of the health of the elderly a high priority today. If the process of aging by individuals is a major cause of age related health declines then postponing aging could be an efficient strategy for improving the health of the elderly. Implementing this strategy requires a better understanding of genetic and non-genetic connections among aging, health, and longevity. We review progress and problems in research areas whose development may contribute to analyses of such connections. These include genetic studies of human aging and longevity, the heterogeneity of populations with respect to their susceptibility to disease and death, forces that shape age patterns of human mortality, secular trends in mortality decline, and integrative mortality modeling using longitudinal data. The dynamic involvement of genetic factors in (i) morbidity/mortality risks, (ii) responses to stresses of life, (iii) multi-morbidities of many elderly individuals, (iv) trade-offs for diseases, (v) genetic heterogeneity, and (vi) other relevant aging-related health declines, underscores the need for a comprehensive, integrated approach to analyze the genetic connections for all of the above aspects of aging-related changes. The dynamic relationships among aging, health, and longevity traits would be better understood if one linked several research fields within one conceptual framework that allowed for efficient analyses of available longitudinal data using the wealth of available knowledge about aging, health, and longevity already accumulated in the research field.

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Published In

Biogerontology

DOI

EISSN

1573-6768

ISSN

1389-5729

Publication Date

February 2016

Volume

17

Issue

1

Start / End Page

89 / 107

Related Subject Headings

  • Survival Rate
  • Stress, Psychological
  • Risk Factors
  • Mortality
  • Models, Genetic
  • Male
  • Longevity
  • Incidence
  • Humans
  • Health Status
 

Citation

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Yashin, A. I., Arbeev, K. G., Arbeeva, L. S., Wu, D., Akushevich, I., Kovtun, M., … Ukraintseva, S. V. (2016). How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity. Biogerontology, 17(1), 89–107. https://doi.org/10.1007/s10522-015-9594-8
Yashin, Anatoliy I., Konstantin G. Arbeev, Liubov S. Arbeeva, Deqing Wu, Igor Akushevich, Mikhail Kovtun, Arseniy Yashkin, et al. “How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Biogerontology 17, no. 1 (February 2016): 89–107. https://doi.org/10.1007/s10522-015-9594-8.
Yashin AI, Arbeev KG, Arbeeva LS, Wu D, Akushevich I, Kovtun M, et al. How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity. Biogerontology. 2016 Feb;17(1):89–107.
Yashin, Anatoliy I., et al. “How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Biogerontology, vol. 17, no. 1, Feb. 2016, pp. 89–107. Epmc, doi:10.1007/s10522-015-9594-8.
Yashin AI, Arbeev KG, Arbeeva LS, Wu D, Akushevich I, Kovtun M, Yashkin A, Kulminski A, Culminskaya I, Stallard E, Li M, Ukraintseva SV. How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity. Biogerontology. 2016 Feb;17(1):89–107.
Journal cover image

Published In

Biogerontology

DOI

EISSN

1573-6768

ISSN

1389-5729

Publication Date

February 2016

Volume

17

Issue

1

Start / End Page

89 / 107

Related Subject Headings

  • Survival Rate
  • Stress, Psychological
  • Risk Factors
  • Mortality
  • Models, Genetic
  • Male
  • Longevity
  • Incidence
  • Humans
  • Health Status