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A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.

Publication ,  Journal Article
Kraus, WE; Granger, CB; Sketch, MH; Donahue, MP; Ginsburg, GS; Hauser, ER; Haynes, C; Newby, LK; Hurdle, M; Dowdy, ZE; Shah, SH
Published in: J Cardiovasc Transl Res
November 2015

The CATHeterization GENetics (CATHGEN) biorepository was assembled in four phases. First, project start-up began in 2000. Second, between 2001 and 2010, we collected clinical data and biological samples from 9334 individuals undergoing cardiac catheterization. Samples were matched at the individual level to clinical data collected at the time of catheterization and stored in the Duke Databank for Cardiovascular Diseases (DDCD). Clinical data included the following: subject demographics (birth date, race, gender, etc.); cardiometabolic history including symptoms; coronary anatomy and cardiac function at catheterization; and fasting chemistry data. Third, as part of the DDCD regular follow-up protocol, yearly evaluations included interim information: vital status (verified via National Death Index search and supplemented by Social Security Death Index search), myocardial infarction (MI), stroke, rehospitalization, coronary revascularization procedures, medication use, and lifestyle habits including smoking. Fourth, samples were used to generate molecular data. CATHGEN offers the opportunity to discover biomarkers and explore mechanisms of cardiovascular disease.

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Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

November 2015

Volume

8

Issue

8

Start / End Page

449 / 457

Location

United States

Related Subject Headings

  • Time Factors
  • Specimen Handling
  • Risk Factors
  • Prognosis
  • Predictive Value of Tests
  • Phenotype
  • Models, Organizational
  • Intellectual Property
  • Humans
  • Genomics
 

Citation

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ICMJE
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Kraus, W. E., Granger, C. B., Sketch, M. H., Donahue, M. P., Ginsburg, G. S., Hauser, E. R., … Shah, S. H. (2015). A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience. J Cardiovasc Transl Res, 8(8), 449–457. https://doi.org/10.1007/s12265-015-9648-y
Kraus, William E., Christopher B. Granger, Michael H. Sketch, Mark P. Donahue, Geoffrey S. Ginsburg, Elizabeth R. Hauser, Carol Haynes, et al. “A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.J Cardiovasc Transl Res 8, no. 8 (November 2015): 449–57. https://doi.org/10.1007/s12265-015-9648-y.
Kraus WE, Granger CB, Sketch MH, Donahue MP, Ginsburg GS, Hauser ER, et al. A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience. J Cardiovasc Transl Res. 2015 Nov;8(8):449–57.
Kraus, William E., et al. “A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.J Cardiovasc Transl Res, vol. 8, no. 8, Nov. 2015, pp. 449–57. Pubmed, doi:10.1007/s12265-015-9648-y.
Kraus WE, Granger CB, Sketch MH, Donahue MP, Ginsburg GS, Hauser ER, Haynes C, Newby LK, Hurdle M, Dowdy ZE, Shah SH. A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience. J Cardiovasc Transl Res. 2015 Nov;8(8):449–457.
Journal cover image

Published In

J Cardiovasc Transl Res

DOI

EISSN

1937-5395

Publication Date

November 2015

Volume

8

Issue

8

Start / End Page

449 / 457

Location

United States

Related Subject Headings

  • Time Factors
  • Specimen Handling
  • Risk Factors
  • Prognosis
  • Predictive Value of Tests
  • Phenotype
  • Models, Organizational
  • Intellectual Property
  • Humans
  • Genomics