Skip to main content

Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia.

Publication ,  Journal Article
Hockenberry, MJ; Krull, KR; Insel, KC; Harris, LL; Gundy, PM; Adkins, KB; Pasvogel, AE; Taylor, OA; Koerner, KM; Montgomery, DW; Ross, AK ...
Published in: Oncology nursing forum
September 2015

To examine associations among oxidative stress, fine and visual-motor abilities, and behavioral adjustment in children receiving chemotherapy for acute lymphoblastic leukemia (ALL)
.A prospective, repeated-measures design
.Two pediatric oncology settings in the southwestern United States.89 children with ALL were followed from diagnosis to the end of chemotherapy.Serial cerebrospinal fluid samples were collected during scheduled lumbar punctures and analyzed for oxidative stress biomarkers. Children completed fine motor dexterity, visual processing speed, and visual-motor integration measures at three time points. Parents completed child behavior ratings at the same times.Oxidative stress, fine motor dexterity, visual processing, visual-motor integration, and behavioral adjustment
.Children with ALL had below-average fine motor dexterity, visual processing speed, and visual-motor integration following the induction phase of ALL therapy. By end of therapy, visual processing speed normalized, and fine motor dexterity and visual-motor integration remained below average. Oxidative stress measures correlated with fine motor dexterity and visual-motor integration. Decreased motor functioning was associated with increased hyperactivity and anxiety
.Oxidative stress occurs following chemo-therapy for childhood ALL and is related to impaired fine motor skills and visual symptoms
.Early intervention should be considered to prevent fine motor and visual-spatial deficits, as well as behavioral problems.

Duke Scholars

Published In

Oncology nursing forum

DOI

EISSN

1538-0688

ISSN

0190-535X

Publication Date

September 2015

Volume

42

Issue

5

Start / End Page

542 / 549

Related Subject Headings

  • Psychomotor Performance
  • Prospective Studies
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxidative Stress
  • Nursing
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Child, Preschool
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hockenberry, M. J., Krull, K. R., Insel, K. C., Harris, L. L., Gundy, P. M., Adkins, K. B., … Moore, I. M. (2015). Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia. Oncology Nursing Forum, 42(5), 542–549. https://doi.org/10.1188/15.onf.542-549
Hockenberry, Marilyn J., Kevin R. Krull, Kathleen C. Insel, Lynnette L. Harris, Patricia M. Gundy, Kristin B. Adkins, Alice E. Pasvogel, et al. “Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia.Oncology Nursing Forum 42, no. 5 (September 2015): 542–49. https://doi.org/10.1188/15.onf.542-549.
Hockenberry MJ, Krull KR, Insel KC, Harris LL, Gundy PM, Adkins KB, et al. Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia. Oncology nursing forum. 2015 Sep;42(5):542–9.
Hockenberry, Marilyn J., et al. “Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia.Oncology Nursing Forum, vol. 42, no. 5, Sept. 2015, pp. 542–49. Epmc, doi:10.1188/15.onf.542-549.
Hockenberry MJ, Krull KR, Insel KC, Harris LL, Gundy PM, Adkins KB, Pasvogel AE, Taylor OA, Koerner KM, Montgomery DW, Ross AK, Hill A, Moore IM. Oxidative Stress, Motor Abilities, and Behavioral Adjustment in Children Treated for Acute Lymphoblastic Leukemia. Oncology nursing forum. 2015 Sep;42(5):542–549.

Published In

Oncology nursing forum

DOI

EISSN

1538-0688

ISSN

0190-535X

Publication Date

September 2015

Volume

42

Issue

5

Start / End Page

542 / 549

Related Subject Headings

  • Psychomotor Performance
  • Prospective Studies
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Oxidative Stress
  • Nursing
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Child, Preschool