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Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data.

Publication ,  Journal Article
Gulack, BC; Englum, BR; Castleberry, AW; Daneshmand, MA; Smith, PK; Perrault, LP
Published in: Ann Cardiothorac Surg
May 2015

Ischemic mitral regurgitation (MR) is a common occurrence following myocardial infarction and its presence is associated with poor outcomes. The optimal treatment of ischemic MR is a matter of debate, especially for patients with moderate MR severity. Some authors advocate for isolated coronary artery bypass grafting (CABG) for patients with moderate MR, maintaining that reverse ventricular remodeling will reduce MR grade and its associated mortality risk, while others argue that a concomitant mitral valve repair (MVR) or replacement is superior. The Cardiothoracic Surgical Trials Network (CTSN) recently published the 1-year results of the Surgical Treatment of Moderate Ischemic Mitral Regurgitation study, a multicenter, randomized, controlled trial investigating the impact of MVR in addition to CABG compared to CABG alone in the treatment of moderate ischemic MR. Here, we have reviewed previous observational and prospective studies investigating moderate ischemic MR treatment as well as the results of the current CTSN randomized trial. Furthermore, we have summarized the current state of the available evidence and preview potential new information that will become available with planned subgroup analyses and further follow-up of enrolled patients in the recently completed CTSN trial.

Duke Scholars

Published In

Ann Cardiothorac Surg

DOI

ISSN

2225-319X

Publication Date

May 2015

Volume

4

Issue

3

Start / End Page

266 / 272

Location

China

Related Subject Headings

  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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ICMJE
MLA
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Gulack, B. C., Englum, B. R., Castleberry, A. W., Daneshmand, M. A., Smith, P. K., & Perrault, L. P. (2015). Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data. Ann Cardiothorac Surg, 4(3), 266–272. https://doi.org/10.3978/j.issn.2225-319X.2015.04.02
Gulack, Brian C., Brian R. Englum, Anthony W. Castleberry, Mani A. Daneshmand, Peter K. Smith, and Louis P. Perrault. “Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data.Ann Cardiothorac Surg 4, no. 3 (May 2015): 266–72. https://doi.org/10.3978/j.issn.2225-319X.2015.04.02.
Gulack BC, Englum BR, Castleberry AW, Daneshmand MA, Smith PK, Perrault LP. Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data. Ann Cardiothorac Surg. 2015 May;4(3):266–72.
Gulack, Brian C., et al. “Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data.Ann Cardiothorac Surg, vol. 4, no. 3, May 2015, pp. 266–72. Pubmed, doi:10.3978/j.issn.2225-319X.2015.04.02.
Gulack BC, Englum BR, Castleberry AW, Daneshmand MA, Smith PK, Perrault LP. Repair or observe moderate ischemic mitral regurgitation during coronary artery bypass grafting? Prospective randomized multicenter data. Ann Cardiothorac Surg. 2015 May;4(3):266–272.

Published In

Ann Cardiothorac Surg

DOI

ISSN

2225-319X

Publication Date

May 2015

Volume

4

Issue

3

Start / End Page

266 / 272

Location

China

Related Subject Headings

  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology