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Cardiorespiratory fitness in breast cancer patients: a call for normative values.

Publication ,  Journal Article
Peel, AB; Thomas, SM; Dittus, K; Jones, LW; Lakoski, SG
Published in: Journal of the American Heart Association
January 2014

There is emerging evidence that adjuvant treatments for breast cancer negatively impact cardiorespiratory fitness (CRF) or Vo2max, a key predictor of cardiovascular risk. Although a number of studies have measured CRF in breast cancer patients, there is currently limited data regarding expected CRF values in this patient population. Given that CRF is a poor prognostic sign and recently highlighted as a key measure to standardize by the American Heart Association, we sought to review the available literature on CRF among breast cancer patients.We identified 27 clinical trials and observational studies measuring Vo2max in the pre- and post-adjuvant treatment setting for breast cancer. We compared Vo2max before to Vo2max after adjuvant therapy and compared Vo2max in female breast cancer patients with Vo2max in healthy controls.We found that CRF was substantially lower in women with a history of breast cancer compared with healthy women and this was most pronounced among breast cancer patients in the post-adjuvant setting. We conclude that knowledge of normative CRF values is critical to tailor appropriately timed exercise interventions in breast cancer patients susceptible to low CRF and subsequent cardiovascular risk.

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Published In

Journal of the American Heart Association

DOI

EISSN

2047-9980

ISSN

2047-9980

Publication Date

January 2014

Volume

3

Issue

1

Start / End Page

e000432

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Survivors
  • Risk Factors
  • Reference Values
  • Radiotherapy, Adjuvant
  • Predictive Value of Tests
  • Physical Fitness
  • Oxygen Consumption
  • Myocardium
 

Citation

APA
Chicago
ICMJE
MLA
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Peel, A. B., Thomas, S. M., Dittus, K., Jones, L. W., & Lakoski, S. G. (2014). Cardiorespiratory fitness in breast cancer patients: a call for normative values. Journal of the American Heart Association, 3(1), e000432. https://doi.org/10.1161/jaha.113.000432
Peel, Amanda B., Samantha M. Thomas, Kim Dittus, Lee W. Jones, and Susan G. Lakoski. “Cardiorespiratory fitness in breast cancer patients: a call for normative values.Journal of the American Heart Association 3, no. 1 (January 2014): e000432. https://doi.org/10.1161/jaha.113.000432.
Peel AB, Thomas SM, Dittus K, Jones LW, Lakoski SG. Cardiorespiratory fitness in breast cancer patients: a call for normative values. Journal of the American Heart Association. 2014 Jan;3(1):e000432.
Peel, Amanda B., et al. “Cardiorespiratory fitness in breast cancer patients: a call for normative values.Journal of the American Heart Association, vol. 3, no. 1, Jan. 2014, p. e000432. Epmc, doi:10.1161/jaha.113.000432.
Peel AB, Thomas SM, Dittus K, Jones LW, Lakoski SG. Cardiorespiratory fitness in breast cancer patients: a call for normative values. Journal of the American Heart Association. 2014 Jan;3(1):e000432.
Journal cover image

Published In

Journal of the American Heart Association

DOI

EISSN

2047-9980

ISSN

2047-9980

Publication Date

January 2014

Volume

3

Issue

1

Start / End Page

e000432

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Survivors
  • Risk Factors
  • Reference Values
  • Radiotherapy, Adjuvant
  • Predictive Value of Tests
  • Physical Fitness
  • Oxygen Consumption
  • Myocardium