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MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.

Publication ,  Journal Article
Song, X; Sturgis, EM; Liu, J; Jin, L; Wang, Z; Zhang, C; Wei, Q; Li, G
Published in: PLoS One
2013

BACKGROUND: Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/inflammation responses to infection, which may control HPV clearance. We thus hypothesized that microRNA polymorphisms modify the association between HPV16 seropositivity and OSCC risk. METHODS: Four single-nucleotide polymorphisms in microRNAs were genotyped and HPV16 serology was determined in 325 cases and 335 matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using univariate and multivariable logistic regression models. RESULTS: Overall, each polymorphism had no significant main effect on OSCC risk. Compared with the risk among individuals with both miR146 rs2910164 GG genotype and HPV16 seronegativity, risk of OSCC was increased among those with CG or CC genotype and HPV16 seronegativity (OR, 1.2; 95% CI, 0.9-1.8), GG genotype and HPV16 seropositivity (OR, 3.0; 95% CI, 1.8-5.0), and CG or CC genotype and HPV16 seropositivity (OR, 4.7; 95% CI, 2.3-9.4). Similar results were found for miR149 rs2292832, miR196 rs11614913, and miR499 rs3746444. Analyses stratified by tumor sites and smoking status showed that each polymorphism significantly increased the risk of HPV16-associated squamous cell carcinoma of the oropharynx (SCCOP), and such effect modification was particularly prominent in never smokers. CONCLUSIONS: Our results indicate that microRNA polymorphisms modify the risk of OSCC associated with HPV16 seropositivity, particularly in patients with SCCOP and never smokers. Larger studies are needed to verify our findings.

Duke Scholars

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

2

Start / End Page

e56622

Location

United States

Related Subject Headings

  • Smoking
  • Serologic Tests
  • Polymorphism, Single Nucleotide
  • Oropharyngeal Neoplasms
  • Middle Aged
  • MicroRNAs
  • Male
  • Humans
  • Human papillomavirus 16
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
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Song, X., Sturgis, E. M., Liu, J., Jin, L., Wang, Z., Zhang, C., … Li, G. (2013). MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers. PLoS One, 8(2), e56622. https://doi.org/10.1371/journal.pone.0056622
Song, Xicheng, Erich M. Sturgis, Jun Liu, Lei Jin, Zhongqiu Wang, Caiyun Zhang, Qingyi Wei, and Guojun Li. “MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.PLoS One 8, no. 2 (2013): e56622. https://doi.org/10.1371/journal.pone.0056622.
Song X, Sturgis EM, Liu J, Jin L, Wang Z, Zhang C, et al. MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers. PLoS One. 2013;8(2):e56622.
Song, Xicheng, et al. “MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.PLoS One, vol. 8, no. 2, 2013, p. e56622. Pubmed, doi:10.1371/journal.pone.0056622.
Song X, Sturgis EM, Liu J, Jin L, Wang Z, Zhang C, Wei Q, Li G. MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers. PLoS One. 2013;8(2):e56622.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

2

Start / End Page

e56622

Location

United States

Related Subject Headings

  • Smoking
  • Serologic Tests
  • Polymorphism, Single Nucleotide
  • Oropharyngeal Neoplasms
  • Middle Aged
  • MicroRNAs
  • Male
  • Humans
  • Human papillomavirus 16
  • Genetic Predisposition to Disease