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Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.

Publication ,  Journal Article
Tyson, CC; Kuchibhatla, M; Patel, UD; Pun, PH; Chang, A; Nwankwo, C; Joseph, MA; Svetkey, LP
Published in: J Hypertens (Los Angel)
2014

OBJECTIVES: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure in adults with hypertension, how kidney function impacts this effect is not known. We evaluated whether Estimated Glomerular Filtration Rate (eGFR) modifies the effect of the DASH diet on blood pressure, markers of mineral metabolism, and markers of kidney function. METHODS: Secondary analysis of the DASH-Sodium trial, a multicenter, randomized, controlled human feeding study that evaluated the blood pressure lowering effect of the DASH diet at three levels of sodium intake. Data from 92 participants with pre-hypertension or stage 1 hypertension during the 3450 mg /day sodium diet assignment contributed to this analysis. Stored frozen plasma and urine specimens were used to measure kidney related laboratory outcomes. RESULTS: Effects of the DASH diet on blood pressure, phosphorus, intact parathyroid hormone, creatinine, and albuminuria were not modified by baseline eGFR (mean 84.5 ± 18.0 ml/min/1.73 m2, range 44.1 to 138.6 ml/min/1.73 m2) or the presence of chronic kidney disease (N=13%). CONCLUSIONS: The impact of the DASH diet on blood pressure, markers of mineral metabolism, and markers of kidney function does not appear to be modified by eGFR in this small subset of DASH-Sodium trial participants with relatively preserved kidney function. Whether greater reduction in eGFR modifies the effects of DASH on kidney related measures is yet to be determined. A larger study in individuals with more advanced kidney disease is needed to establish the efficacy and safety of the DASH diet in this patient population.

Duke Scholars

Published In

J Hypertens (Los Angel)

DOI

ISSN

2167-1095

Publication Date

2014

Volume

3

Location

United States
 

Citation

APA
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ICMJE
MLA
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Tyson, C. C., Kuchibhatla, M., Patel, U. D., Pun, P. H., Chang, A., Nwankwo, C., … Svetkey, L. P. (2014). Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet. J Hypertens (Los Angel), 3. https://doi.org/10.4172/2167-1095.1000168
Tyson, Crystal C., Maragatha Kuchibhatla, Uptal D. Patel, Patrick H. Pun, Alex Chang, Chinazo Nwankwo, Michael A. Joseph, and Laura P. Svetkey. “Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.J Hypertens (Los Angel) 3 (2014). https://doi.org/10.4172/2167-1095.1000168.
Tyson CC, Kuchibhatla M, Patel UD, Pun PH, Chang A, Nwankwo C, et al. Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet. J Hypertens (Los Angel). 2014;3.
Tyson, Crystal C., et al. “Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.J Hypertens (Los Angel), vol. 3, 2014. Pubmed, doi:10.4172/2167-1095.1000168.
Tyson CC, Kuchibhatla M, Patel UD, Pun PH, Chang A, Nwankwo C, Joseph MA, Svetkey LP. Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet. J Hypertens (Los Angel). 2014;3.

Published In

J Hypertens (Los Angel)

DOI

ISSN

2167-1095

Publication Date

2014

Volume

3

Location

United States