Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.
Publication
, Journal Article
Saelens, JW; Lau-Bonilla, D; Moller, A; Medina, N; Guzmán, B; Calderón, M; Herrera, R; Sisk, DM; Xet-Mull, AM; Stout, JE; Arathoon, E ...
Published in: Tuberculosis (Edinb)
December 2015
Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence and drug resistance, but there have been only a few cases reported in Central America. Here we report the first whole genome sequencing of Central American Beijing-lineage strains of Mtb. We find that multiple Beijing-lineage strains, derived from independent founding events, are currently circulating in Guatemala, but overall still represent a relatively small proportion of disease burden. Finally, we identify a specific Beijing-lineage outbreak centered on a poor neighborhood in Guatemala City.
Duke Scholars
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Published In
Tuberculosis (Edinb)
DOI
EISSN
1873-281X
Publication Date
December 2015
Volume
95
Issue
6
Start / End Page
810 / 816
Location
Scotland
Related Subject Headings
- Urban Health
- Tuberculosis
- Sequence Analysis, DNA
- Predictive Value of Tests
- Poverty
- Polymorphism, Single Nucleotide
- Phylogeny
- Phenotype
- Mycobacterium tuberculosis
- Molecular Epidemiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Saelens, J. W., Lau-Bonilla, D., Moller, A., Medina, N., Guzmán, B., Calderón, M., … Tobin, D. M. (2015). Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak. Tuberculosis (Edinb), 95(6), 810–816. https://doi.org/10.1016/j.tube.2015.09.001
Saelens, Joseph W., Dalia Lau-Bonilla, Anneliese Moller, Narda Medina, Brenda Guzmán, Maylena Calderón, Raúl Herrera, et al. “Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.” Tuberculosis (Edinb) 95, no. 6 (December 2015): 810–16. https://doi.org/10.1016/j.tube.2015.09.001.
Saelens JW, Lau-Bonilla D, Moller A, Medina N, Guzmán B, Calderón M, et al. Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak. Tuberculosis (Edinb). 2015 Dec;95(6):810–6.
Saelens, Joseph W., et al. “Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak.” Tuberculosis (Edinb), vol. 95, no. 6, Dec. 2015, pp. 810–16. Pubmed, doi:10.1016/j.tube.2015.09.001.
Saelens JW, Lau-Bonilla D, Moller A, Medina N, Guzmán B, Calderón M, Herrera R, Sisk DM, Xet-Mull AM, Stout JE, Arathoon E, Samayoa B, Tobin DM. Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak. Tuberculosis (Edinb). 2015 Dec;95(6):810–816.
Published In
Tuberculosis (Edinb)
DOI
EISSN
1873-281X
Publication Date
December 2015
Volume
95
Issue
6
Start / End Page
810 / 816
Location
Scotland
Related Subject Headings
- Urban Health
- Tuberculosis
- Sequence Analysis, DNA
- Predictive Value of Tests
- Poverty
- Polymorphism, Single Nucleotide
- Phylogeny
- Phenotype
- Mycobacterium tuberculosis
- Molecular Epidemiology