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Using mathematical models to understand metabolism, genes, and disease.

Publication ,  Journal Article
Nijhout, HF; Best, JA; Reed, MC
Published in: BMC biology
September 2015

Mathematical models are a useful tool for investigating a large number of questions in metabolism, genetics, and gene-environment interactions. A model based on the underlying biology and biochemistry is a platform for in silico biological experimentation that can reveal the causal chain of events that connect variation in one quantity to variation in another. We discuss how we construct such models, how we have used them to investigate homeostatic mechanisms, gene-environment interactions, and genotype-phenotype mapping, and how they can be used in precision and personalized medicine.

Duke Scholars

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Published In

BMC biology

DOI

EISSN

1741-7007

ISSN

1741-7007

Publication Date

September 2015

Volume

13

Start / End Page

79

Related Subject Headings

  • Precision Medicine
  • Models, Biological
  • Humans
  • Homeostasis
  • Gene-Environment Interaction
  • Developmental Biology
  • Computer Simulation
  • Chromosome Mapping
  • 31 Biological sciences
  • 06 Biological Sciences
 

Citation

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Nijhout, H. F., Best, J. A., & Reed, M. C. (2015). Using mathematical models to understand metabolism, genes, and disease. BMC Biology, 13, 79. https://doi.org/10.1186/s12915-015-0189-2
Nijhout, H Frederik, Janet A. Best, and Michael C. Reed. “Using mathematical models to understand metabolism, genes, and disease.BMC Biology 13 (September 2015): 79. https://doi.org/10.1186/s12915-015-0189-2.
Nijhout HF, Best JA, Reed MC. Using mathematical models to understand metabolism, genes, and disease. BMC biology. 2015 Sep;13:79.
Nijhout, H. Frederik, et al. “Using mathematical models to understand metabolism, genes, and disease.BMC Biology, vol. 13, Sept. 2015, p. 79. Epmc, doi:10.1186/s12915-015-0189-2.
Nijhout HF, Best JA, Reed MC. Using mathematical models to understand metabolism, genes, and disease. BMC biology. 2015 Sep;13:79.
Journal cover image

Published In

BMC biology

DOI

EISSN

1741-7007

ISSN

1741-7007

Publication Date

September 2015

Volume

13

Start / End Page

79

Related Subject Headings

  • Precision Medicine
  • Models, Biological
  • Humans
  • Homeostasis
  • Gene-Environment Interaction
  • Developmental Biology
  • Computer Simulation
  • Chromosome Mapping
  • 31 Biological sciences
  • 06 Biological Sciences