Skip to main content

Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.

Publication ,  Journal Article
Wu, Q; Cao, X; Yan, D; Wang, D; Aballay, A
Published in: J Biol Chem
December 4, 2015

Increasing evidence indicates that immune responses to microbial infections may contribute to neurodegenerative diseases. Here, we show that Pseudomonas aeruginosa infection of Caenorhabditis elegans causes a number of neural changes that are hallmarks of neurodegeneration. Using an unbiased genetic screen to identify genes involved in the control of P. aeruginosa-induced neurodegeneration, we identified mes-1, which encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germ line. We showed that sterile but not fertile mes-1 animals were resistant to neurodegeneration induced by P. aeruginosa infection. Similar results were observed using animals carrying a mutation in the maternal effect gene pgl-1, which is required for postembryonic germ line development, and the germ line-deficient strains glp-1 and glp-4. Additional studies indicated that the FOXO transcription factor DAF-16 is required for resistance to P. aeruginosa-induced neurodegeneration in germ line-deficient strains. Thus, our results demonstrate that P. aeruginosa infection results in neurodegeneration phenotypes in C. elegans that are controlled by the germ line in a cell-nonautonomous manner.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Biol Chem

DOI

EISSN

1083-351X

Publication Date

December 4, 2015

Volume

290

Issue

49

Start / End Page

29231 / 29239

Location

United States

Related Subject Headings

  • RNA Interference
  • Pseudomonas aeruginosa
  • Pseudomonas Infections
  • Phenotype
  • Osmotic Pressure
  • Neurodegenerative Diseases
  • Mutation
  • Immunity, Innate
  • Host-Pathogen Interactions
  • Green Fluorescent Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, Q., Cao, X., Yan, D., Wang, D., & Aballay, A. (2015). Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans. J Biol Chem, 290(49), 29231–29239. https://doi.org/10.1074/jbc.M115.674259
Wu, Qiuli, Xiou Cao, Dong Yan, Dayong Wang, and Alejandro Aballay. “Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.J Biol Chem 290, no. 49 (December 4, 2015): 29231–39. https://doi.org/10.1074/jbc.M115.674259.
Wu, Qiuli, et al. “Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.J Biol Chem, vol. 290, no. 49, Dec. 2015, pp. 29231–39. Pubmed, doi:10.1074/jbc.M115.674259.

Published In

J Biol Chem

DOI

EISSN

1083-351X

Publication Date

December 4, 2015

Volume

290

Issue

49

Start / End Page

29231 / 29239

Location

United States

Related Subject Headings

  • RNA Interference
  • Pseudomonas aeruginosa
  • Pseudomonas Infections
  • Phenotype
  • Osmotic Pressure
  • Neurodegenerative Diseases
  • Mutation
  • Immunity, Innate
  • Host-Pathogen Interactions
  • Green Fluorescent Proteins