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Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management.

Publication ,  Journal Article
Crowley, MJ; Olsen, MK; Woolson, SL; King, HA; Oddone, EZ; Bosworth, HB
Published in: J Clin Hypertens (Greenwich)
April 2016

Telemedicine-based medication management improves hypertension control, but has been evaluated primarily in patients with low antihypertensive drug counts. Its impact on patients taking three or more antihypertensive agents is not well-established. To address this evidence gap, the authors conducted an exploratory analysis of an 18-month, 591-patient trial of telemedicine-based hypertension medication management. Using general linear models, the effect of medication management on blood pressure for patients taking two or fewer antihypertensive agents at study baseline vs those taking three or more was compared. While patients taking two or fewer antihypertensive agents had a significant reduction in systolic blood pressure with medication management, those taking three or more had no such response. The between-subgroup effect difference was statistically significant at 6 months (-6.4 mm Hg [95% confidence interval, -12.2 to -0.6]) and near significant at 18 months (-6.0 mm Hg [95% confidence interval, -12.2 to 0.2]). These findings suggest that baseline antihypertensive drug count may impact how patients respond to hypertension medication management and emphasize the need to study management strategies specifically in patients taking three or more antihypertensive medications.

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Published In

J Clin Hypertens (Greenwich)

DOI

EISSN

1751-7176

Publication Date

April 2016

Volume

18

Issue

4

Start / End Page

322 / 328

Location

United States

Related Subject Headings

  • Time Factors
  • Telemedicine
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Follow-Up Studies
  • Drug Utilization
  • Drug Therapy, Combination
  • Disease Management
 

Citation

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Crowley, M. J., Olsen, M. K., Woolson, S. L., King, H. A., Oddone, E. Z., & Bosworth, H. B. (2016). Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management. J Clin Hypertens (Greenwich), 18(4), 322–328. https://doi.org/10.1111/jch.12669
Crowley, Matthew J., Maren K. Olsen, Sandra L. Woolson, Heather A. King, Eugene Z. Oddone, and Hayden B. Bosworth. “Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management.J Clin Hypertens (Greenwich) 18, no. 4 (April 2016): 322–28. https://doi.org/10.1111/jch.12669.
Crowley MJ, Olsen MK, Woolson SL, King HA, Oddone EZ, Bosworth HB. Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management. J Clin Hypertens (Greenwich). 2016 Apr;18(4):322–8.
Crowley, Matthew J., et al. “Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management.J Clin Hypertens (Greenwich), vol. 18, no. 4, Apr. 2016, pp. 322–28. Pubmed, doi:10.1111/jch.12669.
Crowley MJ, Olsen MK, Woolson SL, King HA, Oddone EZ, Bosworth HB. Baseline Antihypertensive Drug Count and Patient Response to Hypertension Medication Management. J Clin Hypertens (Greenwich). 2016 Apr;18(4):322–328.
Journal cover image

Published In

J Clin Hypertens (Greenwich)

DOI

EISSN

1751-7176

Publication Date

April 2016

Volume

18

Issue

4

Start / End Page

322 / 328

Location

United States

Related Subject Headings

  • Time Factors
  • Telemedicine
  • Middle Aged
  • Male
  • Hypertension
  • Humans
  • Follow-Up Studies
  • Drug Utilization
  • Drug Therapy, Combination
  • Disease Management