Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.
Publication
, Journal Article
Gonzalez-Gronow, M; Cuchacovich, M; Francos, R; Cuchacovich, S; Blanco, A; Sandoval, R; Gomez, CF; Valenzuela, JA; Ray, R; Pizzo, SV
Published in: J Neuroimmunol
October 15, 2015
Autoantibodies from autistic spectrum disorder (ASD) patients react with multiple proteins expressed in the brain. One such autoantibody targets myelin basic protein (MBP). ASD patients have autoantibodies to MBP of both the IgG and IgA classes in high titers, but no autoantibodies of the IgM class. IgA autoantibodies act as serine proteinases and degrade MBP in vitro. They also induce a decrease in long-term potentiation in the hippocampi of rats either perfused with or previously inoculated with this IgA. Because this class of autoantibody causes myelin sheath destruction in multiple sclerosis (MS), we hypothesized a similar pathological role for them in ASD.
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Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
October 15, 2015
Volume
287
Start / End Page
1 / 8
Location
Netherlands
Related Subject Headings
- Synaptic Transmission
- Rats, Sprague-Dawley
- Rats
- Proteolysis
- Patch-Clamp Techniques
- Neurology & Neurosurgery
- Myelin Basic Protein
- Male
- Long-Term Potentiation
- Leupeptins
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Gonzalez-Gronow, M., Cuchacovich, M., Francos, R., Cuchacovich, S., Blanco, A., Sandoval, R., … Pizzo, S. V. (2015). Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. J Neuroimmunol, 287, 1–8. https://doi.org/10.1016/j.jneuroim.2015.07.006
Gonzalez-Gronow, Mario, Miguel Cuchacovich, Rina Francos, Stephanie Cuchacovich, Angel Blanco, Rodrigo Sandoval, Cristian Farias Gomez, Javier A. Valenzuela, Rupa Ray, and Salvatore V. Pizzo. “Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.” J Neuroimmunol 287 (October 15, 2015): 1–8. https://doi.org/10.1016/j.jneuroim.2015.07.006.
Gonzalez-Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Blanco A, Sandoval R, et al. Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. J Neuroimmunol. 2015 Oct 15;287:1–8.
Gonzalez-Gronow, Mario, et al. “Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus.” J Neuroimmunol, vol. 287, Oct. 2015, pp. 1–8. Pubmed, doi:10.1016/j.jneuroim.2015.07.006.
Gonzalez-Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Blanco A, Sandoval R, Gomez CF, Valenzuela JA, Ray R, Pizzo SV. Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus. J Neuroimmunol. 2015 Oct 15;287:1–8.
Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
October 15, 2015
Volume
287
Start / End Page
1 / 8
Location
Netherlands
Related Subject Headings
- Synaptic Transmission
- Rats, Sprague-Dawley
- Rats
- Proteolysis
- Patch-Clamp Techniques
- Neurology & Neurosurgery
- Myelin Basic Protein
- Male
- Long-Term Potentiation
- Leupeptins