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Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth.

Publication ,  Journal Article
Lee, JH; Park, CM; Lee, SM; Kim, H; McAdams, HP; Goo, JM
Published in: Eur Radiol
June 2016

OBJECTIVE: To investigate the natural course of persistent pulmonary subsolid nodules (SSNs) with solid portions ≤5 mm and the clinico-radiological features that influence interval growth over follow-ups. METHODS: From 2005 to 2013, the natural courses of 213 persistent SSNs in 213 patients were evaluated. To identify significant predictors of interval growth, Kaplan-Meier analysis and Cox proportional hazard regression analysis were performed. RESULTS: Among the 213 nodules, 136 were pure ground-glass nodules (GGNs; growth, 18; stable, 118) and 77 were part-solid GGNs with solid portions ≤5 mm (growth, 24; stable, 53). For all SSNs, lung cancer history (p = 0.001), part-solid GGNs (p < 0.001), and nodule diameter (p < 0.001) were significant predictors for interval growth. On subgroup analysis, nodule diameter was an independent predictor for the interval growth of both pure GGNs (p < 0.001), and part-solid GGNs (p = 0.037). For part-solid GGNs, lung cancer history (p = 0.002) was another significant predictor of the interval growth. Interval growth of pure GGNs ≥10 mm and part-solid GGNs ≥8 mm were significantly more frequent than in pure GGNs <10 mm (p < 0.001) and part-solid GGNs <8 mm (p = 0.003), respectively. CONCLUSION: The natural course of SSNs with solid portions ≤5 mm differed significantly according to their nodule type and nodule diameters, with which their management can be subdivided. KEY POINTS: • Pure GGNs ≥10 mm have significantly more frequent interval growth than those <10 mm. • Part-solid GGNs ≥8 mm have significantly more frequent interval growth than those <8 mm. • Management of SSNs with solid portions ≤5 mm can be subdivided by diameter.

Duke Scholars

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

June 2016

Volume

26

Issue

6

Start / End Page

1529 / 1537

Location

Germany

Related Subject Headings

  • Young Adult
  • Tumor Burden
  • Tomography, X-Ray Computed
  • Solitary Pulmonary Nodule
  • Retrospective Studies
  • Proportional Hazards Models
  • Nuclear Medicine & Medical Imaging
  • Multiple Pulmonary Nodules
  • Middle Aged
  • Male
 

Citation

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ICMJE
MLA
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Lee, J. H., Park, C. M., Lee, S. M., Kim, H., McAdams, H. P., & Goo, J. M. (2016). Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth. Eur Radiol, 26(6), 1529–1537. https://doi.org/10.1007/s00330-015-4017-4
Lee, Jong Hyuk, Chang Min Park, Sang Min Lee, Hyungjin Kim, H Page McAdams, and Jin Mo Goo. “Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth.Eur Radiol 26, no. 6 (June 2016): 1529–37. https://doi.org/10.1007/s00330-015-4017-4.
Lee JH, Park CM, Lee SM, Kim H, McAdams HP, Goo JM. Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth. Eur Radiol. 2016 Jun;26(6):1529–37.
Lee, Jong Hyuk, et al. “Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth.Eur Radiol, vol. 26, no. 6, June 2016, pp. 1529–37. Pubmed, doi:10.1007/s00330-015-4017-4.
Lee JH, Park CM, Lee SM, Kim H, McAdams HP, Goo JM. Persistent pulmonary subsolid nodules with solid portions of 5 mm or smaller: Their natural course and predictors of interval growth. Eur Radiol. 2016 Jun;26(6):1529–1537.
Journal cover image

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

June 2016

Volume

26

Issue

6

Start / End Page

1529 / 1537

Location

Germany

Related Subject Headings

  • Young Adult
  • Tumor Burden
  • Tomography, X-Ray Computed
  • Solitary Pulmonary Nodule
  • Retrospective Studies
  • Proportional Hazards Models
  • Nuclear Medicine & Medical Imaging
  • Multiple Pulmonary Nodules
  • Middle Aged
  • Male