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The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.

Publication ,  Journal Article
DerHovanessian, A; Weigt, SS; Palchevskiy, V; Shino, MY; Sayah, DM; Gregson, AL; Noble, PW; Palmer, SM; Fishbein, MC; Kubak, BM; Ardehali, A ...
Published in: Am J Transplant
February 2016

Primary graft dysfunction (PGD) is a possible risk factor for bronchiolitis obliterans syndrome (BOS) following lung transplantation; however, the mechanism for any such association is poorly understood. Based on the association of TGF-β with acute and chronic inflammatory disorders, we hypothesized that it might play a role in the continuum between PGD and BOS. Thus, the association between PGD and BOS was assessed in a single-center cohort of lung transplant recipients. Bronchoalveolar lavage fluid concentrations of TGF-β and procollagen collected within 24 h of transplantation were compared across the spectrum of PGD, and incorporated into Cox models of BOS. Immunohistochemistry localized expression of TGF-β and its receptor in early lung biopsies posttransplant. We found an association between PGD and BOS in both bilateral and single lung recipients with a hazard ratio of 3.07 (95% CI 1.76-5.38) for the most severe form of PGD. TGF-β and procollagen concentrations were elevated during PGD (p < 0.01), and associated with increased rates of BOS. Expression of TGF-β and its receptor localized to allograft infiltrating mononuclear and stromal cells, and the airway epithelium. These findings validate the association between PGD and the subsequent development of BOS, and suggest that this association may be mediated by receptor/TGF-β biology.

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Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2016

Volume

16

Issue

2

Start / End Page

640 / 649

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Surgery
  • Severity of Illness Index
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Prospective Studies
  • Prognosis
  • Primary Graft Dysfunction
  • Postoperative Complications
 

Citation

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DerHovanessian, A., Weigt, S. S., Palchevskiy, V., Shino, M. Y., Sayah, D. M., Gregson, A. L., … Belperio, J. A. (2016). The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. Am J Transplant, 16(2), 640–649. https://doi.org/10.1111/ajt.13475
DerHovanessian, A., S. S. Weigt, V. Palchevskiy, M. Y. Shino, D. M. Sayah, A. L. Gregson, P. W. Noble, et al. “The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.Am J Transplant 16, no. 2 (February 2016): 640–49. https://doi.org/10.1111/ajt.13475.
DerHovanessian A, Weigt SS, Palchevskiy V, Shino MY, Sayah DM, Gregson AL, et al. The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. Am J Transplant. 2016 Feb;16(2):640–9.
DerHovanessian, A., et al. “The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.Am J Transplant, vol. 16, no. 2, Feb. 2016, pp. 640–49. Pubmed, doi:10.1111/ajt.13475.
DerHovanessian A, Weigt SS, Palchevskiy V, Shino MY, Sayah DM, Gregson AL, Noble PW, Palmer SM, Fishbein MC, Kubak BM, Ardehali A, Ross DJ, Saggar R, Lynch JP, Elashoff RM, Belperio JA. The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. Am J Transplant. 2016 Feb;16(2):640–649.
Journal cover image

Published In

Am J Transplant

DOI

EISSN

1600-6143

Publication Date

February 2016

Volume

16

Issue

2

Start / End Page

640 / 649

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • Surgery
  • Severity of Illness Index
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Prospective Studies
  • Prognosis
  • Primary Graft Dysfunction
  • Postoperative Complications