Skip to main content

Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience.

Publication ,  Journal Article
DeVito, N; Henderson, E; Han, G; Reed, D; Bui, MM; Lavey, R; Robinson, L; Zager, JS; Gonzalez, RJ; Sondak, VK; Letson, GD; Conley, A
Published in: PLoS One
2015

Solitary fibrous tumor (SFT) is a mesenchymal neoplasm of fibrous origin. The 2013 WHO classification of soft tissue tumors defines malignant forms as hypercellular, mitotically active (>4 mitosis/10 high-power fields), with cytological atypia, tumor necrosis, and/or infiltrative margins. With an IRB-approved protocol, we investigated patient records and clinicopathologic data from our Sarcoma Database to describe the clinical characteristics of both benign and malignant SFT. All pathology specimens were reviewed by two pathologists. Descriptive statistics and univariate/multivariate survival analysis were performed. Patient records and Social Security Death Index were used to evaluate vital status. Of 82 patients, 47 (57%) were women and 73 (89%) were Caucasian. Median age was 62 years (range, 20 to 89). Thirty-two (39%) patients succumbed to the disease. Primary tumor site was lung/pleura in 28 (34%), abdomen/pelvis in 23 (28%), extremity in 13 (16%), and head/neck in 9 (11%) patients. Pathology was described as benign in 42 (51%) and malignant in 40 (49%) patients. Compared to benign SFT, malignant histology is associated with larger tumor size, higher mitotic counts, metastatic disease at diagnosis, and greater use of chemotherapy and radiation therapy. Gender, age, and tumor site were not significantly different between benign and malignant subtypes. By univariate analysis, only benign vs. malignant variant and complete resection positively impacted overall survival (P = 0.02 and P<0.0001, respectively). In the multivariable analysis of overall survival, receiving chemotherapy or not receiving surgery were two variables significantly associated with higher failure rate in overall survival: patients with chemotherapy vs. no chemotherapy (P = 0.003, HR = 4.55, with 95% CI: 1.68-12.34) and patients without surgery vs. with surgery (P = 0.005, HR = 25.49, with 95% CI: 2.62-247.57). Clear survival differences exist between benign and malignant SFT. While surgery appears to be the best treatment option for benign and malignant SFT, better systemic therapies are needed to improve outcomes of patients with metastatic, malignant SFT.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

10

Start / End Page

e0140362

Location

United States

Related Subject Headings

  • Survival Analysis
  • Solitary Fibrous Tumors
  • Respiratory Tract Neoplasms
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • Gastrointestinal Neoplasms
  • Female
  • Aged, 80 and over
 

Citation

APA
Chicago
ICMJE
MLA
NLM
DeVito, N., Henderson, E., Han, G., Reed, D., Bui, M. M., Lavey, R., … Conley, A. (2015). Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience. PLoS One, 10(10), e0140362. https://doi.org/10.1371/journal.pone.0140362
DeVito, Nicholas, Evita Henderson, Gang Han, Damon Reed, Marilyn M. Bui, Robert Lavey, Lary Robinson, et al. “Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience.PLoS One 10, no. 10 (2015): e0140362. https://doi.org/10.1371/journal.pone.0140362.
DeVito N, Henderson E, Han G, Reed D, Bui MM, Lavey R, et al. Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience. PLoS One. 2015;10(10):e0140362.
DeVito, Nicholas, et al. “Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience.PLoS One, vol. 10, no. 10, 2015, p. e0140362. Pubmed, doi:10.1371/journal.pone.0140362.
DeVito N, Henderson E, Han G, Reed D, Bui MM, Lavey R, Robinson L, Zager JS, Gonzalez RJ, Sondak VK, Letson GD, Conley A. Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience. PLoS One. 2015;10(10):e0140362.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

10

Start / End Page

e0140362

Location

United States

Related Subject Headings

  • Survival Analysis
  • Solitary Fibrous Tumors
  • Respiratory Tract Neoplasms
  • Middle Aged
  • Male
  • Humans
  • General Science & Technology
  • Gastrointestinal Neoplasms
  • Female
  • Aged, 80 and over