Notch signalling in B cells.
Notch signalling is likely to regulate multiple aspects of lymphoid development and function. During T cell development, Notch signalling is required for commitment of the earliest progenitor, and may also function during other developmental stages. T cell commitment from a common lymphoid progenitor occurs at the expense of B cell development, suggesting that Notch signalling inhibits the earliest stage of B lymphopoiesis. In contrast, recent evidence suggests that Notch promotes the development of marginal zone lymphocytes. Not only is Notch required for later stages of B cell development, but several viral proteins appear to utilize Notch signalling in B cells to mediate their functions. In this review, we will focus on potential roles of Notch signalling in B lymphopoiesis and also consider how viral proteins may utilize Notch signalling in B cells.
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Related Subject Headings
- Viral Proteins
- Thymus Gland
- T-Lymphocytes
- Signal Transduction
- Receptors, Notch
- Models, Biological
- Membrane Proteins
- Leukemia, B-Cell
- Humans
- Gene Expression Regulation, Developmental
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Viral Proteins
- Thymus Gland
- T-Lymphocytes
- Signal Transduction
- Receptors, Notch
- Models, Biological
- Membrane Proteins
- Leukemia, B-Cell
- Humans
- Gene Expression Regulation, Developmental