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The complex interplay between metabolism and apoptosis

Publication ,  Journal Article
Lindblom, K; Kornbluth, S
November 1, 2014

Energy balance is essential for cells to function properly and proliferate. Sufficient nutrient quantities are required for energy and the synthesis of building blocks of cellular structures such as lipid membranes, proteins, and nucleic acids. In contrast, nutrient excess can increase ER stress and reactive oxygen species, leading to cellular damage and apoptosis. In this chapter, we detail three important aspects of the interplay between metabolism and apoptosis: the mechanisms by which metabolic imbalances regulate major signaling effectors in apoptosis, how metabolism itself can be controlled by apoptotic proteins, and the major disease states affected when perturbations in metabolism modulate apoptosis.

Duke Scholars

DOI

Publication Date

November 1, 2014

Volume

9781461493020

Start / End Page

189 / 209
 

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Lindblom, K., & Kornbluth, S. (2014). The complex interplay between metabolism and apoptosis, 9781461493020, 189–209. https://doi.org/10.1007/978-1-4614-9302-0_9
Lindblom, K., and S. Kornbluth. “The complex interplay between metabolism and apoptosis” 9781461493020 (November 1, 2014): 189–209. https://doi.org/10.1007/978-1-4614-9302-0_9.
Lindblom K, Kornbluth S. The complex interplay between metabolism and apoptosis. 2014 Nov 1;9781461493020:189–209.
Lindblom, K., and S. Kornbluth. The complex interplay between metabolism and apoptosis. Vol. 9781461493020, Nov. 2014, pp. 189–209. Scopus, doi:10.1007/978-1-4614-9302-0_9.
Lindblom K, Kornbluth S. The complex interplay between metabolism and apoptosis. 2014 Nov 1;9781461493020:189–209.

DOI

Publication Date

November 1, 2014

Volume

9781461493020

Start / End Page

189 / 209