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The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial

Publication ,  Journal Article
Chandrasiri, UP; Fowkes, F; Richards, JS; Langer, C; Fan, Y-M; Taylor, SM; Beeson, JG; Dewey, KG; Maleta, K; Ashorn, P; Rogerson, SJ
Published in: Malaria Journal
2015

© 2015 Chandrasiri et al.; licensee BioMed Central.Background: Malaria and undernutrition frequently coexist, especially in pregnant women and young children. Nutrient supplementation of these vulnerable groups might reduce their susceptibility to malaria by improving immunity. Methods: Antibody immunity to antigens expressed by a placental-binding parasite isolate, a non-placental binding parasite isolate, merozoites and schizonts at enrolment (before 20 gestation weeks) and at 36 gestation weeks were measured in 1,009 Malawian pregnant women receiving a daily lipid-based nutrient supplement, multiple micronutrients or iron and folic acid, who were participants in a randomized clinical trial assessing the effects of nutrient supplementation on pregnancy outcomes and child development(registration ID: NCT01239693). Results: Antibodies to placental-binding isolates significantly increased while antibodies to most merozoite antigens declined over pregnancy. Overall, after adjustment for covariates, the type of supplementation did not influence antibody levels at 36 gestation weeks or the rate of change in antibody levels from enrolment to 36 weeks. A negative association between maternal body mass index and opsonizing antibodies to placental-binding antigens (coefficient (95% CI) -1.04 (-1.84, -0.24), was observed. Similarly, women with higher socioeconomic status had significantly lower IgG and opsonizing antibodies to placental-binding antigens. Neither of these associations was significantly influenced by the supplementation type. Conclusions: In the current cohort nutrient supplementation did not affect anti-malarial antibody responses, but poor and undernourished mothers should be a priority group in future trials.

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Published In

Malaria Journal

DOI

ISSN

1475-2875

Publication Date

2015

Related Subject Headings

  • Tropical Medicine
  • 1117 Public Health and Health Services
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

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Chandrasiri, U. P., Fowkes, F., Richards, J. S., Langer, C., Fan, Y.-M., Taylor, S. M., … Rogerson, S. J. (2015). The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. Malaria Journal. https://doi.org/10.1186/s12936-015-0707-2
Chandrasiri, U. P., F. Fowkes, J. S. Richards, C. Langer, Y. -. M. Fan, S. M. Taylor, J. G. Beeson, et al. “The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.” Malaria Journal, 2015. https://doi.org/10.1186/s12936-015-0707-2.
Chandrasiri UP, Fowkes F, Richards JS, Langer C, Fan Y-M, Taylor SM, et al. The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. Malaria Journal. 2015;
Chandrasiri, U. P., et al. “The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial.” Malaria Journal, 2015. Scival, doi:10.1186/s12936-015-0707-2.
Chandrasiri UP, Fowkes F, Richards JS, Langer C, Fan Y-M, Taylor SM, Beeson JG, Dewey KG, Maleta K, Ashorn P, Rogerson SJ. The impact of lipid-based nutrient supplementation on anti-malarial antibodies in pregnant women in a randomized controlled trial. Malaria Journal. 2015;
Journal cover image

Published In

Malaria Journal

DOI

ISSN

1475-2875

Publication Date

2015

Related Subject Headings

  • Tropical Medicine
  • 1117 Public Health and Health Services
  • 1108 Medical Microbiology
  • 0605 Microbiology