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Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium.

Publication ,  Journal Article
Olsen, EA; Hodak, E; Anderson, T; Carter, JB; Henderson, M; Cooper, K; Lim, HW
Published in: J Am Acad Dermatol
January 2016

BACKGROUND: Ultraviolet light (UVL) is a long established treatment for mycosis fungoides (MF) and Sézary syndrome (SS), subtypes of cutaneous T-cell lymphoma (CTCL). Treatments have traditionally included broadband, narrowband ultraviolet B light (UVB) and psoralen plus ultraviolet A light photochemotherapy (PUVA), but more recently, treatment options have expanded to include UVA1 and excimer laser. UVL is used either as monotherapy or as an adjuvant to systemic therapy, demonstrating efficacy in many cases that equal or surpass systemic medications. Despite its utility and duration of use, the current practice of using UVL guidelines for psoriasis to treat patients with MF/SS is problematic because the goals of prolonging survival and preventing disease progression are unique to CTCL compared to psoriasis. OBJECTIVES: We sought to develop separate guidelines for phototherapy for MF/SS for both clinical practice and for clinical trials. METHODS: Literature review and cutaneous lymphoma expert consensus group recommendations. RESULTS: This paper reviews the published literature for UVB and UVA/PUVA in MF/SS and suggests practical standardized guidelines for their use. LIMITATIONS: New standardization of phototherapy. CONCLUSIONS: These guidelines should allow the comparison of results with phototherapy in MF/SS across different stages of patients, centers, and in combination with other agents in practice and in clinical trials.

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Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

January 2016

Volume

74

Issue

1

Start / End Page

27 / 58

Location

United States

Related Subject Headings

  • United States
  • Ultraviolet Therapy
  • Treatment Outcome
  • Societies, Medical
  • Skin Neoplasms
  • Sezary Syndrome
  • Risk Assessment
  • Prognosis
  • Practice Guidelines as Topic
  • Phototherapy
 

Citation

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Chicago
ICMJE
MLA
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Olsen, E. A., Hodak, E., Anderson, T., Carter, J. B., Henderson, M., Cooper, K., & Lim, H. W. (2016). Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium. J Am Acad Dermatol, 74(1), 27–58. https://doi.org/10.1016/j.jaad.2015.09.033
Olsen, Elise A., Emilia Hodak, Thomas Anderson, Joi B. Carter, Marsha Henderson, Kevin Cooper, and Henry W. Lim. “Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium.J Am Acad Dermatol 74, no. 1 (January 2016): 27–58. https://doi.org/10.1016/j.jaad.2015.09.033.
Olsen EA, Hodak E, Anderson T, Carter JB, Henderson M, Cooper K, et al. Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium. J Am Acad Dermatol. 2016 Jan;74(1):27–58.
Olsen, Elise A., et al. “Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium.J Am Acad Dermatol, vol. 74, no. 1, Jan. 2016, pp. 27–58. Pubmed, doi:10.1016/j.jaad.2015.09.033.
Olsen EA, Hodak E, Anderson T, Carter JB, Henderson M, Cooper K, Lim HW. Guidelines for phototherapy of mycosis fungoides and Sézary syndrome: A consensus statement of the United States Cutaneous Lymphoma Consortium. J Am Acad Dermatol. 2016 Jan;74(1):27–58.
Journal cover image

Published In

J Am Acad Dermatol

DOI

EISSN

1097-6787

Publication Date

January 2016

Volume

74

Issue

1

Start / End Page

27 / 58

Location

United States

Related Subject Headings

  • United States
  • Ultraviolet Therapy
  • Treatment Outcome
  • Societies, Medical
  • Skin Neoplasms
  • Sezary Syndrome
  • Risk Assessment
  • Prognosis
  • Practice Guidelines as Topic
  • Phototherapy