Signaling Pathways in Liver Diseases: Third Edition
Sirtuins
Publication
, Chapter
Huynh, FK; Mcdonnell, E; Anderson, KA; Hirschey, MD
September 28, 2015
The mammalian sirtuins are a family of seven NAD+-dependent deacetylase enzymes that regulate a wide range of hepatic functions. Altered sirtuin expression in model organisms results in pleiotropic hepatic dysfunction. Furthermore, altered sirtuin expression in humans is associated with hepatic diseases including NAFLD, NASH, and HCC. In this chapter, we review the known biology of the seven sirtuins and the areas of emerging interest in this exciting field.
Duke Scholars
DOI
ISBN
9781118663394
Publication Date
September 28, 2015
Start / End Page
374 / 384
Citation
APA
Chicago
ICMJE
MLA
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Huynh, F. K., Mcdonnell, E., Anderson, K. A., & Hirschey, M. D. (2015). Sirtuins. In Signaling Pathways in Liver Diseases: Third Edition (pp. 374–384). https://doi.org/10.1002/9781118663387.ch27
Huynh, F. K., E. Mcdonnell, K. A. Anderson, and M. D. Hirschey. “Sirtuins.” In Signaling Pathways in Liver Diseases: Third Edition, 374–84, 2015. https://doi.org/10.1002/9781118663387.ch27.
Huynh FK, Mcdonnell E, Anderson KA, Hirschey MD. Sirtuins. In: Signaling Pathways in Liver Diseases: Third Edition. 2015. p. 374–84.
Huynh, F. K., et al. “Sirtuins.” Signaling Pathways in Liver Diseases: Third Edition, 2015, pp. 374–84. Scopus, doi:10.1002/9781118663387.ch27.
Huynh FK, Mcdonnell E, Anderson KA, Hirschey MD. Sirtuins. Signaling Pathways in Liver Diseases: Third Edition. 2015. p. 374–384.
DOI
ISBN
9781118663394
Publication Date
September 28, 2015
Start / End Page
374 / 384