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Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.

Publication ,  Journal Article
Englum, BR; Rothman, J; Leonard, S; Reiter, A; Thornburg, C; Brindle, M; Wright, N; Heeney, MM; Jason Smithers, C; Brown, RL; Kalfa, T ...
Published in: J Pediatr Surg
January 2016

PURPOSE: The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD). METHODS: The Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using random effects mixed modeling, we evaluated the association of operative type with change in hemoglobin, reticulocyte counts, and bilirubin. We also compared laparoscopic to open splenectomy. RESULTS: The analysis included 130 children, with 62.3% (n=81) undergoing TS. For children with HS, all hematologic measures improved after TS, including a 4.1g/dl increase in hemoglobin. Hematologic parameters also improved after PS, although the response was less robust (hemoglobin increase 2.4 g/dl, p<0.001). For children with SCD, there was no change in hemoglobin. Laparoscopy was not associated with differences in hematologic outcomes compared to open. TS and laparoscopy were associated with shorter length of stay. CONCLUSION: Children with HS have an excellent hematologic response after TS or PS, although the hematologic response is more robust following TS. Children with SCD have smaller changes in their hematologic parameters. These data offer guidance to families and clinicians considering TS or PS.

Duke Scholars

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

January 2016

Volume

51

Issue

1

Start / End Page

122 / 127

Location

United States

Related Subject Headings

  • Splenectomy
  • Spherocytosis, Hereditary
  • Reticulocyte Count
  • Registries
  • Pediatrics
  • Male
  • Laparoscopy
  • Humans
  • Hemoglobins
  • Female
 

Citation

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MLA
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Englum, B. R., Rothman, J., Leonard, S., Reiter, A., Thornburg, C., Brindle, M., … Splenectomy in Congenital Hemolytic Anemia Consortium, . (2016). Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg, 51(1), 122–127. https://doi.org/10.1016/j.jpedsurg.2015.10.028
Englum, Brian R., Jennifer Rothman, Sarah Leonard, Audra Reiter, Courtney Thornburg, Mary Brindle, Nicola Wright, et al. “Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.J Pediatr Surg 51, no. 1 (January 2016): 122–27. https://doi.org/10.1016/j.jpedsurg.2015.10.028.
Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, et al. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg. 2016 Jan;51(1):122–7.
Englum, Brian R., et al. “Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.J Pediatr Surg, vol. 51, no. 1, Jan. 2016, pp. 122–27. Pubmed, doi:10.1016/j.jpedsurg.2015.10.028.
Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Jason Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter SD, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Rice HE, Splenectomy in Congenital Hemolytic Anemia Consortium. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg. 2016 Jan;51(1):122–127.
Journal cover image

Published In

J Pediatr Surg

DOI

EISSN

1531-5037

Publication Date

January 2016

Volume

51

Issue

1

Start / End Page

122 / 127

Location

United States

Related Subject Headings

  • Splenectomy
  • Spherocytosis, Hereditary
  • Reticulocyte Count
  • Registries
  • Pediatrics
  • Male
  • Laparoscopy
  • Humans
  • Hemoglobins
  • Female