A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.
Publication
, Journal Article
Ding, S; Veillette, M; Coutu, M; Prévost, J; Scharf, L; Bjorkman, PJ; Ferrari, G; Robinson, JE; Stürzel, C; Hahn, BH; Sauter, D; Kirchhoff, F ...
Published in: J Virol
February 15, 2016
Previous studies have shown that sera from HIV-1-infected individuals contain antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC). These antibodies preferentially recognize envelope glycoprotein (Env) epitopes induced upon CD4 binding. Here, we show that a highly conserved tryptophan at position 69 of the gp120 inner domain is important for ADCC mediated by anti-cluster A antibodies and sera from HIV-1-infected individuals.
Duke Scholars
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Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
February 15, 2016
Volume
90
Issue
4
Start / End Page
2127 / 2134
Location
United States
Related Subject Headings
- Virology
- Humans
- HIV-1
- HIV Envelope Protein gp120
- HIV Antibodies
- Conserved Sequence
- Antibody-Dependent Cell Cytotoxicity
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 30 Agricultural, veterinary and food sciences
Citation
APA
Chicago
ICMJE
MLA
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Ding, S., Veillette, M., Coutu, M., Prévost, J., Scharf, L., Bjorkman, P. J., … Finzi, A. (2016). A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies. J Virol, 90(4), 2127–2134. https://doi.org/10.1128/JVI.02779-15
Ding, Shilei, Maxime Veillette, Mathieu Coutu, Jérémie Prévost, Louise Scharf, Pamela J. Bjorkman, Guido Ferrari, et al. “A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.” J Virol 90, no. 4 (February 15, 2016): 2127–34. https://doi.org/10.1128/JVI.02779-15.
Ding S, Veillette M, Coutu M, Prévost J, Scharf L, Bjorkman PJ, et al. A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies. J Virol. 2016 Feb 15;90(4):2127–34.
Ding, Shilei, et al. “A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies.” J Virol, vol. 90, no. 4, Feb. 2016, pp. 2127–34. Pubmed, doi:10.1128/JVI.02779-15.
Ding S, Veillette M, Coutu M, Prévost J, Scharf L, Bjorkman PJ, Ferrari G, Robinson JE, Stürzel C, Hahn BH, Sauter D, Kirchhoff F, Lewis GK, Pazgier M, Finzi A. A Highly Conserved Residue of the HIV-1 gp120 Inner Domain Is Important for Antibody-Dependent Cellular Cytotoxicity Responses Mediated by Anti-cluster A Antibodies. J Virol. 2016 Feb 15;90(4):2127–2134.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
February 15, 2016
Volume
90
Issue
4
Start / End Page
2127 / 2134
Location
United States
Related Subject Headings
- Virology
- Humans
- HIV-1
- HIV Envelope Protein gp120
- HIV Antibodies
- Conserved Sequence
- Antibody-Dependent Cell Cytotoxicity
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 30 Agricultural, veterinary and food sciences