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Novel diagnostic and therapeutic approaches to pancreatic cancer

Publication ,  Journal Article
Abbruzzese, JL
Published in: Cancer Bulletin
December 1, 1994

PANCREATIC CANCER is highly resistant to therapy. The traditional treatment modalities of surgery, radiotherapy, and chemotherapy, singly or in combination, have made little impact on this disease; however, basic scientific research has improved our understanding of the biology of pancreatic cancer, resulting in identification of a number of targets that could be exploited in future clinical trials. These include the K-ras oncogene, potentially valuable in early detection strategies and as a target for gene and drug therapies; paracrine and autocrine growth factors, providing novel targets for intervention using chemical or biologic agents; and transgenic models of pancreatic cancer, providing insights into the important molecular events involved in pancreatic carcinogenesis, as well as providing information on pancreas-specific enhancer/promoter sequences that may allow selective expression of target proteins in pancreatic cancer cells.

Duke Scholars

Published In

Cancer Bulletin

ISSN

0740-820X

Publication Date

December 1, 1994

Volume

46

Issue

6

Start / End Page

525 / 531
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Abbruzzese, J. L. (1994). Novel diagnostic and therapeutic approaches to pancreatic cancer. Cancer Bulletin, 46(6), 525–531.
Abbruzzese, J. L. “Novel diagnostic and therapeutic approaches to pancreatic cancer.” Cancer Bulletin 46, no. 6 (December 1, 1994): 525–31.
Abbruzzese JL. Novel diagnostic and therapeutic approaches to pancreatic cancer. Cancer Bulletin. 1994 Dec 1;46(6):525–31.
Abbruzzese, J. L. “Novel diagnostic and therapeutic approaches to pancreatic cancer.” Cancer Bulletin, vol. 46, no. 6, Dec. 1994, pp. 525–31.
Abbruzzese JL. Novel diagnostic and therapeutic approaches to pancreatic cancer. Cancer Bulletin. 1994 Dec 1;46(6):525–531.

Published In

Cancer Bulletin

ISSN

0740-820X

Publication Date

December 1, 1994

Volume

46

Issue

6

Start / End Page

525 / 531