Skip to main content
Journal cover image

Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study.

Publication ,  Journal Article
Hassan, MM; Abbruzzese, JL; Bondy, ML; Wolff, RA; Vauthey, J-N; Pisters, PW; Evans, DB; Khan, R; Lenzi, R; Jiao, L; Li, D
Published in: Cancer
June 15, 2007

BACKGROUND: The associations between passive smoking and the use of noncigarette tobacco products with pancreatic cancer are not clear. METHODS: In this case-control study, the authors collected information on passive smoking and the use of noncigarette tobacco products in 808 patients with pancreatic adenocarcinoma and 808 healthy controls by personal interview. Multivariable logistic regression was performed to estimate the adjusted odds ratio (AOR) and 95% confidence interval (95% CI). RESULTS: The results confirmed the previously reported association between active smoking and increased risk for pancreatic cancer. The AOR was 1.7 (95% CI, 1.4-2.2) for regular smokers, 1.8 (95% CI, 1.4-2.4) for long-term smokers, and 3.1 (95% CI, 2.2-4.3) for former smokers. Although passive smoking showed a nonsignificantly elevated risk for pancreatic cancer in the entire study population (AOR, 1.3; 95% CI, 0.9-1.7), the association was present among ever smokers (AOR, 1.7; 95% CI, 1.03-2.6) but was absent among never smokers (AOR, 1.1; 95% CI, 0.8-1.6). Neither intensity nor duration of passive smoking modified the risk of pancreatic cancer among never smokers. The use of chewing tobacco, snuff, and pipes showed no significant risk elevation for pancreatic cancer after controlling for the confounding effects of demographics and other known risk factors. The use of cigars in never smokers showed a borderline significant increase of risk for pancreatic cancer (AOR, 2.2; 95% CI, 1.0-4.7; P = .05). CONCLUSIONS: The current observations did not support a role for passive smoking or the use of noncigarette tobacco products in the etiology of pancreatic cancer. The association between cigar use and the risk of pancreatic cancer needs to be confirmed in other study populations.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

June 15, 2007

Volume

109

Issue

12

Start / End Page

2547 / 2556

Location

United States

Related Subject Headings

  • United States
  • Tobacco, Smokeless
  • Tobacco Smoke Pollution
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hassan, M. M., Abbruzzese, J. L., Bondy, M. L., Wolff, R. A., Vauthey, J.-N., Pisters, P. W., … Li, D. (2007). Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study. Cancer, 109(12), 2547–2556. https://doi.org/10.1002/cncr.22724
Hassan, Manal M., James L. Abbruzzese, Melissa L. Bondy, Robert A. Wolff, Jean-Nicolas Vauthey, Peter W. Pisters, Douglas B. Evans, et al. “Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study.Cancer 109, no. 12 (June 15, 2007): 2547–56. https://doi.org/10.1002/cncr.22724.
Hassan MM, Abbruzzese JL, Bondy ML, Wolff RA, Vauthey J-N, Pisters PW, et al. Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study. Cancer. 2007 Jun 15;109(12):2547–56.
Hassan, Manal M., et al. “Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study.Cancer, vol. 109, no. 12, June 2007, pp. 2547–56. Pubmed, doi:10.1002/cncr.22724.
Hassan MM, Abbruzzese JL, Bondy ML, Wolff RA, Vauthey J-N, Pisters PW, Evans DB, Khan R, Lenzi R, Jiao L, Li D. Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study. Cancer. 2007 Jun 15;109(12):2547–2556.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

June 15, 2007

Volume

109

Issue

12

Start / End Page

2547 / 2556

Location

United States

Related Subject Headings

  • United States
  • Tobacco, Smokeless
  • Tobacco Smoke Pollution
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male