Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.
Publication
, Journal Article
Xie, K; Abbruzzese, JL
Published in: Cancer Cell
October 2003
The hedgehog (Hh) signaling pathway plays many roles in invertebrate and vertebrate development. For example, specific inhibition of sonic Hh expression is critical during early stages of pancreas organogenesis, but an active Hh pathway appears to be required for maintenance of adult endocrine functions. Mutational inactivation of the Hh pathway has been demonstrated in human malignancies of the skin, cerebellum, and skeletal muscle. Now, two papers implicate aberrant Hh signaling in human upper gastrointestinal cancers including those developing from the esophagus, stomach, biliary tract, and pancreas.
Duke Scholars
Published In
Cancer Cell
DOI
ISSN
1535-6108
Publication Date
October 2003
Volume
4
Issue
4
Start / End Page
245 / 247
Location
United States
Related Subject Headings
- Zinc Finger Protein GLI1
- Transcription Factors
- Trans-Activators
- Smad Proteins
- Signal Transduction
- Pancreas
- Oncology & Carcinogenesis
- Oncogene Proteins
- Mutation
- Morphogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Xie, K., & Abbruzzese, J. L. (2003). Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. Cancer Cell, 4(4), 245–247. https://doi.org/10.1016/s1535-6108(03)00246-0
Xie, Keping, and James L. Abbruzzese. “Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.” Cancer Cell 4, no. 4 (October 2003): 245–47. https://doi.org/10.1016/s1535-6108(03)00246-0.
Xie K, Abbruzzese JL. Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. Cancer Cell. 2003 Oct;4(4):245–7.
Xie, Keping, and James L. Abbruzzese. “Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers.” Cancer Cell, vol. 4, no. 4, Oct. 2003, pp. 245–47. Pubmed, doi:10.1016/s1535-6108(03)00246-0.
Xie K, Abbruzzese JL. Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. Cancer Cell. 2003 Oct;4(4):245–247.
Published In
Cancer Cell
DOI
ISSN
1535-6108
Publication Date
October 2003
Volume
4
Issue
4
Start / End Page
245 / 247
Location
United States
Related Subject Headings
- Zinc Finger Protein GLI1
- Transcription Factors
- Trans-Activators
- Smad Proteins
- Signal Transduction
- Pancreas
- Oncology & Carcinogenesis
- Oncogene Proteins
- Mutation
- Morphogenesis