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Experimental animal models of pancreatic carcinogenesis and metastasis.

Publication ,  Journal Article
Wei, D; Xiong, HQ; Abbruzzese, JL; Xie, K
Published in: Int J Gastrointest Cancer
2003

Pancreatic cancer is a lethal disease characterized by early metastasis, local invasion, and resistance to conventional therapies. To understand its etiology and eventually make prevention of it possible and effective, appropriate carcinogenesis models will certainly help us understand the effects of environmental and genetic elements on pancreatic carcinogenesis. The development of new treatment strategies to control cancer metastasis is of immediate urgency. Fulfillment of this task relies on our knowledge of the cellular and molecular biology of pancreatic cancer metastasis and the availability of biologically and clinically relevant model systems. Many of the existing pancreatic cancer carcinogenesis and metastasis animal models are described in this review. The advantages and disadvantages of each model and their clinical implications are discussed, and special attention is focused on experimental therapeutic strategies targeting pancreatic cancer metastasis.

Duke Scholars

Published In

Int J Gastrointest Cancer

DOI

ISSN

1537-3649

Publication Date

2003

Volume

33

Issue

1

Start / End Page

43 / 60

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Neoplasm Metastasis
  • Models, Animal
  • Humans
  • Cell Transformation, Neoplastic
  • Animals
 

Citation

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Wei, D., Xiong, H. Q., Abbruzzese, J. L., & Xie, K. (2003). Experimental animal models of pancreatic carcinogenesis and metastasis. Int J Gastrointest Cancer, 33(1), 43–60. https://doi.org/10.1385/IJGC:33:1:43
Wei, Daoyan, Henry Q. Xiong, James L. Abbruzzese, and Keping Xie. “Experimental animal models of pancreatic carcinogenesis and metastasis.Int J Gastrointest Cancer 33, no. 1 (2003): 43–60. https://doi.org/10.1385/IJGC:33:1:43.
Wei D, Xiong HQ, Abbruzzese JL, Xie K. Experimental animal models of pancreatic carcinogenesis and metastasis. Int J Gastrointest Cancer. 2003;33(1):43–60.
Wei, Daoyan, et al. “Experimental animal models of pancreatic carcinogenesis and metastasis.Int J Gastrointest Cancer, vol. 33, no. 1, 2003, pp. 43–60. Pubmed, doi:10.1385/IJGC:33:1:43.
Wei D, Xiong HQ, Abbruzzese JL, Xie K. Experimental animal models of pancreatic carcinogenesis and metastasis. Int J Gastrointest Cancer. 2003;33(1):43–60.
Journal cover image

Published In

Int J Gastrointest Cancer

DOI

ISSN

1537-3649

Publication Date

2003

Volume

33

Issue

1

Start / End Page

43 / 60

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Neoplasm Metastasis
  • Models, Animal
  • Humans
  • Cell Transformation, Neoplastic
  • Animals