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Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms

Publication ,  Journal Article
Coker, WJ; Jeter, A; Schade, H; Kang, Y
Published in: Biomarker Research
December 2013

Highly active antiretroviral therapy (HAART) has significantly improved the outcome and survival of human immunodeficiency virus (HIV)-infected patients. Subsequently, long-term morbidities including cancer have become of major public health and clinical interest for this patient population. Plasma cell disorders occur at higher incidence in HIV-infected patients; however, the molecular mechanisms driving the plasma cell disease process and the optimal management for these patients remain to be defined. This article provides an up-to-date review of the characteristics and management of HIV-infected patients with plasma cell disorders. We first present 3 cases of plasma cell disorders in HIV-infected patients, ranging from polyclonal hypergammaglobulinemia to symptomatic multiple myeloma. We then discuss the epidemiology, clinical presentation, and management of each of these plasma cell disorders, with an emphasis on the molecular events underlying the progression of plasma cell diseases from monoclonal gammopathy to symptomatic multiple myeloma. We propose a three-step hypothesis for the development of multiple myeloma. Finally, we discuss the use of high dose chemotherapy and autologous hematopoietic stem cell transplantation in the treatment of HIV-infected patients with multiple myeloma. Our review includes the care of HIV-infected patients with plasma cell disorders in the current era of HAART and novel agents available for the treatment of multiple myeloma.

Duke Scholars

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Published In

Biomarker Research

DOI

EISSN

2050-7771

Publication Date

December 2013

Volume

1

Issue

1

Publisher

Springer Science and Business Media LLC

Related Subject Headings

  • 3209 Neurosciences
  • 3206 Medical biotechnology
  • 3202 Clinical sciences
 

Citation

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ICMJE
MLA
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Coker, W. J., Jeter, A., Schade, H., & Kang, Y. (2013). Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms. Biomarker Research, 1(1). https://doi.org/10.1186/2050-7771-1-8
Coker, Woodrow J., Ashley Jeter, Henning Schade, and Yubin Kang. “Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms.” Biomarker Research 1, no. 1 (December 2013). https://doi.org/10.1186/2050-7771-1-8.
Coker WJ, Jeter A, Schade H, Kang Y. Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms. Biomarker Research. 2013 Dec;1(1).
Coker, Woodrow J., et al. “Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms.” Biomarker Research, vol. 1, no. 1, Springer Science and Business Media LLC, Dec. 2013. Crossref, doi:10.1186/2050-7771-1-8.
Coker WJ, Jeter A, Schade H, Kang Y. Plasma cell disorders in HIV-infected patients: epidemiology and molecular mechanisms. Biomarker Research. Springer Science and Business Media LLC; 2013 Dec;1(1).
Journal cover image

Published In

Biomarker Research

DOI

EISSN

2050-7771

Publication Date

December 2013

Volume

1

Issue

1

Publisher

Springer Science and Business Media LLC

Related Subject Headings

  • 3209 Neurosciences
  • 3206 Medical biotechnology
  • 3202 Clinical sciences