Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins.
Publication
, Journal Article
Khattar, SK; DeVico, AL; LaBranche, CC; Panda, A; Montefiori, DC; Samal, SK
Published in: J Virol
February 1, 2016
Newcastle disease virus (NDV) expressing HIV-1 BaL gp160 was evaluated either alone or with monomeric BaL gp120 and BaL SOSIP gp140 protein in a prime-boost combination in guinea pigs to enhance envelope (Env)-specific humoral and mucosal immune responses. We showed that a regimen consisting of an NDV prime followed by a protein boost elicited stronger serum and mucosal Th-1-biased IgG responses and neutralizing antibody responses than NDV-only immunizations. Additionally, these responses were higher after the gp120 than after the SOSIP gp140 protein boost.
Duke Scholars
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
February 1, 2016
Volume
90
Issue
3
Start / End Page
1682 / 1686
Location
United States
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Vaccines, Synthetic
- Vaccination
- Th1 Cells
- Newcastle disease virus
- Neutralization Tests
- Injections, Intramuscular
- Immunoglobulin G
- Immunization Schedule
Citation
APA
Chicago
ICMJE
MLA
NLM
Khattar, S. K., DeVico, A. L., LaBranche, C. C., Panda, A., Montefiori, D. C., & Samal, S. K. (2016). Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins. J Virol, 90(3), 1682–1686. https://doi.org/10.1128/JVI.02847-15
Khattar, Sunil K., Anthony L. DeVico, Celia C. LaBranche, Aruna Panda, David C. Montefiori, and Siba K. Samal. “Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins.” J Virol 90, no. 3 (February 1, 2016): 1682–86. https://doi.org/10.1128/JVI.02847-15.
Khattar SK, DeVico AL, LaBranche CC, Panda A, Montefiori DC, Samal SK. Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins. J Virol. 2016 Feb 1;90(3):1682–6.
Khattar, Sunil K., et al. “Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins.” J Virol, vol. 90, no. 3, Feb. 2016, pp. 1682–86. Pubmed, doi:10.1128/JVI.02847-15.
Khattar SK, DeVico AL, LaBranche CC, Panda A, Montefiori DC, Samal SK. Enhanced Immune Responses to HIV-1 Envelope Elicited by a Vaccine Regimen Consisting of Priming with Newcastle Disease Virus Expressing HIV gp160 and Boosting with gp120 and SOSIP gp140 Proteins. J Virol. 2016 Feb 1;90(3):1682–1686.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
February 1, 2016
Volume
90
Issue
3
Start / End Page
1682 / 1686
Location
United States
Related Subject Headings
- env Gene Products, Human Immunodeficiency Virus
- Virology
- Vaccines, Synthetic
- Vaccination
- Th1 Cells
- Newcastle disease virus
- Neutralization Tests
- Injections, Intramuscular
- Immunoglobulin G
- Immunization Schedule