The Emerging Role of ABL Kinases in Solid Tumors.
Publication
, Journal Article
Wang, J; Pendergast, AM
Published in: Trends Cancer
October 1, 2015
The Abelson (ABL) tyrosine kinases were identified as drivers of leukemia in mice and humans. Emerging data has shown a role for the ABL family kinases, ABL1 and ABL2, in the progression of several solid tumors. This review will focus on recent reports of the involvement of the ABL kinases in tumor progression using mouse models as well as recent data generated from genomic and proteomic studies linking enhanced expression and hyper-activation of the ABL kinases to some human cancers. Preclinical studies on small molecule inhibitors of the ABL kinases suggest that their use may have beneficial effects for the treatment of selected solid tumors.
Duke Scholars
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Published In
Trends Cancer
DOI
ISSN
2405-8033
Publication Date
October 1, 2015
Volume
1
Issue
2
Start / End Page
110 / 123
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Wang, J., & Pendergast, A. M. (2015). The Emerging Role of ABL Kinases in Solid Tumors. Trends Cancer, 1(2), 110–123. https://doi.org/10.1016/j.trecan.2015.07.004
Wang, Jun, and Ann Marie Pendergast. “The Emerging Role of ABL Kinases in Solid Tumors.” Trends Cancer 1, no. 2 (October 1, 2015): 110–23. https://doi.org/10.1016/j.trecan.2015.07.004.
Wang J, Pendergast AM. The Emerging Role of ABL Kinases in Solid Tumors. Trends Cancer. 2015 Oct 1;1(2):110–23.
Wang, Jun, and Ann Marie Pendergast. “The Emerging Role of ABL Kinases in Solid Tumors.” Trends Cancer, vol. 1, no. 2, Oct. 2015, pp. 110–23. Pubmed, doi:10.1016/j.trecan.2015.07.004.
Wang J, Pendergast AM. The Emerging Role of ABL Kinases in Solid Tumors. Trends Cancer. 2015 Oct 1;1(2):110–123.
Published In
Trends Cancer
DOI
ISSN
2405-8033
Publication Date
October 1, 2015
Volume
1
Issue
2
Start / End Page
110 / 123
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 1112 Oncology and Carcinogenesis