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Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients.

Publication ,  Journal Article
Applebaum, E; Nackley, AG; Bair, E; Maixner, W; Khan, AA
Published in: J Endod
August 2015

INTRODUCTION: Nonsteroidal anti-inflammatory drugs (NSAIDs) have a well-established analgesic efficacy for inflammatory pain. These drugs exert their effect by inhibiting the enzyme cyclooxygenase (COX) and are commonly used for the management of pain after endodontic treatment. There are 2 distinct isoforms of COX: COX-1, which is constitutively expressed, and COX-2, which is primarily induced by inflammation. Previous studies have shown that functional human genetic variants of the COX-2 gene may explain individual variations in acute pain. The present study extends this work by examining the potential contribution of the 2 COX isoforms to pain after endodontic treatment. METHODS: Ninety-four patients treated by endodontic residents at the University of North Carolina School of Dentistry were enrolled into a prospective cohort study. Data on potential predictors of post-treatment pain were collected, and all patients submitted saliva samples for genetic analysis. Nonsurgical root canal therapy was performed, and participants recorded pain levels for 5 days after. RESULTS: In this study, 63% of patients experienced at least mild pain after root canal therapy, and 24% experienced moderate to severe pain. The presence of pretreatment pain was correlated with higher post-treatment pain (P = .01). Elevated heart rate (P = .02) and higher diastolic blood pressure (P = .024) were also correlated with decreased post-treatment pain. Finally, we identified genetic variants in COX-2 (haplotype composed of rs2383515 G, rs5277 G, rs5275 T, and rs2206593 A) associated with post-treatment pain after endodontic treatment (P = .025). CONCLUSIONS: Understanding the genetic basis of pain after endodontic treatment will advance its prevention and management.

Duke Scholars

Published In

J Endod

DOI

EISSN

1878-3554

Publication Date

August 2015

Volume

41

Issue

8

Start / End Page

1214 / 1218

Location

United States

Related Subject Headings

  • Young Adult
  • Universities
  • Root Canal Therapy
  • Prospective Studies
  • Prevalence
  • Polymorphism, Single Nucleotide
  • Pain
  • North Carolina
  • Middle Aged
  • Male
 

Citation

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ICMJE
MLA
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Applebaum, E., Nackley, A. G., Bair, E., Maixner, W., & Khan, A. A. (2015). Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients. J Endod, 41(8), 1214–1218. https://doi.org/10.1016/j.joen.2015.04.021
Applebaum, Elizabeth, Andrea G. Nackley, Eric Bair, William Maixner, and Asma A. Khan. “Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients.J Endod 41, no. 8 (August 2015): 1214–18. https://doi.org/10.1016/j.joen.2015.04.021.
Applebaum E, Nackley AG, Bair E, Maixner W, Khan AA. Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients. J Endod. 2015 Aug;41(8):1214–8.
Applebaum, Elizabeth, et al. “Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients.J Endod, vol. 41, no. 8, Aug. 2015, pp. 1214–18. Pubmed, doi:10.1016/j.joen.2015.04.021.
Applebaum E, Nackley AG, Bair E, Maixner W, Khan AA. Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients. J Endod. 2015 Aug;41(8):1214–1218.
Journal cover image

Published In

J Endod

DOI

EISSN

1878-3554

Publication Date

August 2015

Volume

41

Issue

8

Start / End Page

1214 / 1218

Location

United States

Related Subject Headings

  • Young Adult
  • Universities
  • Root Canal Therapy
  • Prospective Studies
  • Prevalence
  • Polymorphism, Single Nucleotide
  • Pain
  • North Carolina
  • Middle Aged
  • Male