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Multisystem dysregulation in painful temporomandibular disorders.

Publication ,  Journal Article
Chen, H; Nackley, A; Miller, V; Diatchenko, L; Maixner, W
Published in: J Pain
September 2013

UNLABELLED: Multiple physiological and psychological regulatory domains may contribute to the pathophysiology of pain in temporomandibular disorder (TMD) and other bodily pain conditions. The purpose of this study was to evaluate the relationship between multisystem dysregulation and the presence of TMD pain, as well as the presence of different numbers of comorbid pain conditions in TMD. Secondary data analysis was conducted in 131 non-TMD (without comorbid pain) controls, 14 TMD subjects without comorbid pain, 78 TMD subjects with 1 comorbid pain, and 67 TMD subjects with multiple comorbid pain conditions who participated in a TMD genetic study. Twenty markers from sensory, autonomic, inflammatory, and psychological domains were evaluated. The results revealed that 1) overall dysregulation in multiple system domains (OR [odds ratio] = 1.6, 95% confidence interval [CI] = 1.4-1.8), particularly in the sensory (OR = 1.9, 95% CI = 1.3-2.9) and the psychological (OR = 2.1, 95% CI = 2.1-2.7) domains, were associated with increased likelihood of being a painful TMD case; and 2) dysregulations in individual system domains were selectively associated with the increased odds of being a TMD case with different levels of comorbid persistent pain conditions. These outcomes indicate that heterogeneous multisystem dysregulations may exist in painful TMD subgroups, and multidimensional physiological and psychological assessments can provide important information regarding pathophysiology, diagnosis, and management of pain in TMD patients. PERSPECTIVE: The concurrent assessment of multiple physiological and psychological systems is critical to our understanding of the pathophysiological processes that contribute to painful TMD and associated comorbid conditions, which will ultimately guide and inform appropriate treatment strategies that address the multisystem dysregulation associated with complex and common persistent pain conditions.

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Published In

J Pain

DOI

EISSN

1528-8447

Publication Date

September 2013

Volume

14

Issue

9

Start / End Page

983 / 996

Location

United States

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Sensation Disorders
  • Retrospective Studies
  • Pain Threshold
  • Pain Measurement
  • Pain
  • Middle Aged
 

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Chen, H., Nackley, A., Miller, V., Diatchenko, L., & Maixner, W. (2013). Multisystem dysregulation in painful temporomandibular disorders. J Pain, 14(9), 983–996. https://doi.org/10.1016/j.jpain.2013.03.011
Chen, Hong, Andrea Nackley, Vanessa Miller, Luda Diatchenko, and William Maixner. “Multisystem dysregulation in painful temporomandibular disorders.J Pain 14, no. 9 (September 2013): 983–96. https://doi.org/10.1016/j.jpain.2013.03.011.
Chen H, Nackley A, Miller V, Diatchenko L, Maixner W. Multisystem dysregulation in painful temporomandibular disorders. J Pain. 2013 Sep;14(9):983–96.
Chen, Hong, et al. “Multisystem dysregulation in painful temporomandibular disorders.J Pain, vol. 14, no. 9, Sept. 2013, pp. 983–96. Pubmed, doi:10.1016/j.jpain.2013.03.011.
Chen H, Nackley A, Miller V, Diatchenko L, Maixner W. Multisystem dysregulation in painful temporomandibular disorders. J Pain. 2013 Sep;14(9):983–996.
Journal cover image

Published In

J Pain

DOI

EISSN

1528-8447

Publication Date

September 2013

Volume

14

Issue

9

Start / End Page

983 / 996

Location

United States

Related Subject Headings

  • Young Adult
  • Temporomandibular Joint Disorders
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Sensation Disorders
  • Retrospective Studies
  • Pain Threshold
  • Pain Measurement
  • Pain
  • Middle Aged