Skip to main content

The phenotypic and genetic signatures of common musculoskeletal pain conditions.

Publication ,  Journal Article
Diatchenko, L; Fillingim, RB; Smith, SB; Maixner, W
Published in: Nat Rev Rheumatol
June 2013

Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in affected individuals and are characterized by a report of pain greater than expected based on the results of a standard physical evaluation. The pathophysiology of these conditions is largely unknown, we lack biological markers for accurate diagnosis, and conventional therapeutics have limited effectiveness. Growing evidence suggests that chronic pain conditions are associated with both physical and psychological triggers, which initiate pain amplification and psychological distress; thus, susceptibility is dictated by complex interactions between genetic and environmental factors. Herein, we review phenotypic and genetic markers of common musculoskeletal pain conditions, selected based on their association with musculoskeletal pain in previous research. The phenotypic markers of greatest interest include measures of pain amplification and 'psychological' measures (such as emotional distress, somatic awareness, psychosocial stress and catastrophizing). Genetic polymorphisms reproducibly linked with musculoskeletal pain are found in genes contributing to serotonergic and adrenergic pathways. Elucidation of the biological mechanisms by which these markers contribute to the perception of pain in these patients will enable the development of novel effective drugs and methodologies that permit better diagnoses and approaches to personalized medicine.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

June 2013

Volume

9

Issue

6

Start / End Page

340 / 350

Location

United States

Related Subject Headings

  • Phenotype
  • Musculoskeletal Pain
  • Humans
  • Genetic Markers
  • Chronic Disease
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diatchenko, L., Fillingim, R. B., Smith, S. B., & Maixner, W. (2013). The phenotypic and genetic signatures of common musculoskeletal pain conditions. Nat Rev Rheumatol, 9(6), 340–350. https://doi.org/10.1038/nrrheum.2013.43
Diatchenko, Luda, Roger B. Fillingim, Shad B. Smith, and William Maixner. “The phenotypic and genetic signatures of common musculoskeletal pain conditions.Nat Rev Rheumatol 9, no. 6 (June 2013): 340–50. https://doi.org/10.1038/nrrheum.2013.43.
Diatchenko L, Fillingim RB, Smith SB, Maixner W. The phenotypic and genetic signatures of common musculoskeletal pain conditions. Nat Rev Rheumatol. 2013 Jun;9(6):340–50.
Diatchenko, Luda, et al. “The phenotypic and genetic signatures of common musculoskeletal pain conditions.Nat Rev Rheumatol, vol. 9, no. 6, June 2013, pp. 340–50. Pubmed, doi:10.1038/nrrheum.2013.43.
Diatchenko L, Fillingim RB, Smith SB, Maixner W. The phenotypic and genetic signatures of common musculoskeletal pain conditions. Nat Rev Rheumatol. 2013 Jun;9(6):340–350.

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

June 2013

Volume

9

Issue

6

Start / End Page

340 / 350

Location

United States

Related Subject Headings

  • Phenotype
  • Musculoskeletal Pain
  • Humans
  • Genetic Markers
  • Chronic Disease
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences