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Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy.

Publication ,  Journal Article
Skarphedinsson, G; Compton, S; Thomsen, PH; Weidle, B; Dahl, K; Nissen, JB; Torp, NC; Hybel, K; Melin, KH; Valderhaug, R; Wentzel-Larsen, T ...
Published in: J Child Adolesc Psychopharmacol
June 2015

OBJECTIVE: The purpose of this study was to investigate whether the presence of tic disorder is negatively associated with sertraline (SRT) outcomes, but not with continued cognitive-behavioral therapy (CBT), in a sample of youth who were unresponsive to an initial full course of CBT. METHODS: In the Nordic Long-Term OCD Study, children and adolescents with OCD who were rated as nonresponders to 14 weeks of open-label CBT were randomized to continued CBT (n=28) or SRT treatment (n=22) for an additional 16 weeks of treatment. We investigated whether the presence or absence of comorbid tic disorder moderated treatment outcomes on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS). RESULTS: Twelve out of 50 (24.0%) participants were diagnosed with comorbid tic disorder, with 7 receiving continued CBT and 5 receiving SRT, respectively. In patients without tic disorder, results showed no significant between-group differences on average CY-BOCS scores. However, in patients with comorbid tic disorder, those who received SRT had significantly lower average CY-BOCS scores than those who received continued CBT. CONCLUSIONS: Children and adolescents with OCD and comorbid tic disorder, who are nonresponders to an initial 14 week course of CBT, may benefit more from a serotonin reuptake inhibitor (SRI) than from continued CBT.

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Published In

J Child Adolesc Psychopharmacol

DOI

EISSN

1557-8992

Publication Date

June 2015

Volume

25

Issue

5

Start / End Page

432 / 439

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tic Disorders
  • Sertraline
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatric Status Rating Scales
  • Obsessive-Compulsive Disorder
  • Humans
  • Developmental & Child Psychology
  • Cognitive Behavioral Therapy
  • Child
 

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Skarphedinsson, G., Compton, S., Thomsen, P. H., Weidle, B., Dahl, K., Nissen, J. B., … Ivarsson, T. (2015). Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy. J Child Adolesc Psychopharmacol, 25(5), 432–439. https://doi.org/10.1089/cap.2014.0167
Skarphedinsson, Gudmundur, Scott Compton, Per Hove Thomsen, Bernhard Weidle, Kitty Dahl, Judith Becker Nissen, Nor Christian Torp, et al. “Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy.J Child Adolesc Psychopharmacol 25, no. 5 (June 2015): 432–39. https://doi.org/10.1089/cap.2014.0167.
Skarphedinsson G, Compton S, Thomsen PH, Weidle B, Dahl K, Nissen JB, et al. Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy. J Child Adolesc Psychopharmacol. 2015 Jun;25(5):432–9.
Skarphedinsson, Gudmundur, et al. “Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy.J Child Adolesc Psychopharmacol, vol. 25, no. 5, June 2015, pp. 432–39. Pubmed, doi:10.1089/cap.2014.0167.
Skarphedinsson G, Compton S, Thomsen PH, Weidle B, Dahl K, Nissen JB, Torp NC, Hybel K, Melin KH, Valderhaug R, Wentzel-Larsen T, Ivarsson T. Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy. J Child Adolesc Psychopharmacol. 2015 Jun;25(5):432–439.
Journal cover image

Published In

J Child Adolesc Psychopharmacol

DOI

EISSN

1557-8992

Publication Date

June 2015

Volume

25

Issue

5

Start / End Page

432 / 439

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tic Disorders
  • Sertraline
  • Selective Serotonin Reuptake Inhibitors
  • Psychiatric Status Rating Scales
  • Obsessive-Compulsive Disorder
  • Humans
  • Developmental & Child Psychology
  • Cognitive Behavioral Therapy
  • Child