Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms
Publication
, Journal Article
Lin, YT; Verma, A; Hodgkinson, CP
Published in: Current Genomics
December 3, 2012
Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease. © 2012 Bentham Science Publishers.
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Published In
Current Genomics
DOI
EISSN
1875-5488
ISSN
1389-2029
Publication Date
December 3, 2012
Volume
13
Issue
8
Start / End Page
633 / 645
Related Subject Headings
- Developmental Biology
- 3105 Genetics
- 0604 Genetics
Citation
APA
Chicago
ICMJE
MLA
NLM
Lin, Y. T., Verma, A., & Hodgkinson, C. P. (2012). Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms. Current Genomics, 13(8), 633–645. https://doi.org/10.2174/138920212803759712
Lin, Y. T., A. Verma, and C. P. Hodgkinson. “Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms.” Current Genomics 13, no. 8 (December 3, 2012): 633–45. https://doi.org/10.2174/138920212803759712.
Lin YT, Verma A, Hodgkinson CP. Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms. Current Genomics. 2012 Dec 3;13(8):633–45.
Lin, Y. T., et al. “Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms.” Current Genomics, vol. 13, no. 8, Dec. 2012, pp. 633–45. Scopus, doi:10.2174/138920212803759712.
Lin YT, Verma A, Hodgkinson CP. Toll-like receptors and human disease: Lessons from single nucleotide polymorphisms. Current Genomics. 2012 Dec 3;13(8):633–645.
Published In
Current Genomics
DOI
EISSN
1875-5488
ISSN
1389-2029
Publication Date
December 3, 2012
Volume
13
Issue
8
Start / End Page
633 / 645
Related Subject Headings
- Developmental Biology
- 3105 Genetics
- 0604 Genetics