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Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages.

Publication ,  Journal Article
Hodgkinson, CP; Ye, S
Published in: Biochem Biophys Res Commun
August 29, 2003

We used a combination of expression microarray and Northern blot analyses to identify target genes for peroxisome proliferator-activated receptor (PPAR) gamma in RAW264.7 macrophages. PPARgamma natural ligand 15-deoxy-Delta(12,14) prostaglandin and synthetic ligands ciglitazone and rosiglitazone increased the expression of scavenger receptor CD36 and ATP-binding cassette transporter A1, as well as adipophilin (a lipid droplet coating protein involved in intracellular lipid storage and transport), calpain (a protease implicated in ABCA1 protein degradation), and ADAM8 (a disintegrin and metalloprotease protein involved in cell adhesion). These findings are relevant to understanding the effect of PPARgamma activation on gene expression and cognate pathways in macrophages.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

August 29, 2003

Volume

308

Issue

3

Start / End Page

505 / 510

Location

United States

Related Subject Headings

  • Transcription Factors
  • Receptors, Cytoplasmic and Nuclear
  • Oligonucleotide Array Sequence Analysis
  • Models, Biological
  • Macrophages
  • Lipid Metabolism
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Cell Line
  • Biochemistry & Molecular Biology
 

Citation

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Hodgkinson, C. P., & Ye, S. (2003). Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages. Biochem Biophys Res Commun, 308(3), 505–510. https://doi.org/10.1016/s0006-291x(03)01416-5
Hodgkinson, Conrad P., and Shu Ye. “Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages.Biochem Biophys Res Commun 308, no. 3 (August 29, 2003): 505–10. https://doi.org/10.1016/s0006-291x(03)01416-5.
Hodgkinson, Conrad P., and Shu Ye. “Microarray analysis of peroxisome proliferator-activated receptor-gamma induced changes in gene expression in macrophages.Biochem Biophys Res Commun, vol. 308, no. 3, Aug. 2003, pp. 505–10. Pubmed, doi:10.1016/s0006-291x(03)01416-5.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

August 29, 2003

Volume

308

Issue

3

Start / End Page

505 / 510

Location

United States

Related Subject Headings

  • Transcription Factors
  • Receptors, Cytoplasmic and Nuclear
  • Oligonucleotide Array Sequence Analysis
  • Models, Biological
  • Macrophages
  • Lipid Metabolism
  • Gene Expression Regulation
  • Gene Expression Profiling
  • Cell Line
  • Biochemistry & Molecular Biology