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Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition.

Publication ,  Journal Article
Carrino, DA; Mesiano, S; Barker, NM; Hurd, WW; Caplan, AI
Published in: Biochem J
April 15, 2012

Fibrosis is the formation of excess and abnormal fibrous connective tissue as a result of either a reparative or reactive process. A defining feature of connective tissue is its extracellular matrix, which provides structural support and also influences cellular activity. Two common human conditions that result from fibrosis are uterine fibroids (leiomyomas) and keloid scars. Because these conditions share a number of similarities and because their growth is due primarily to excessive extracellular matrix deposition, we compared the proteoglycans of uterine fibroids and keloid scars with corresponding normal tissues. Our analysis indicates that uterine fibroids and keloid scars contain higher amounts of glycosaminoglycans relative to normal myometrium and normal adult skin respectively. Proteoglycan composition is also different in the fibrotic tissues. Compared with unaffected tissues, uterine fibroids and keloid scars contain higher relative amounts of versican and lower relative amounts of decorin. There is also evidence for a higher level of versican catabolism in the fibrotic tissues compared with unaffected tissues. These qualitative and quantitative proteoglycan differences may play a role in the expansion of these fibroses and in their excessive matrix deposition and matrix disorganization, due to effects on cell proliferation, TGF (transforming growth factor)-β signalling and/or collagen fibril formation.

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Published In

Biochem J

DOI

EISSN

1470-8728

Publication Date

April 15, 2012

Volume

443

Issue

2

Start / End Page

361 / 368

Location

England

Related Subject Headings

  • Young Adult
  • Proteoglycans
  • Middle Aged
  • Leiomyoma
  • Keloid
  • Humans
  • Female
  • Extracellular Matrix
  • Biochemistry & Molecular Biology
  • Adult
 

Citation

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Carrino, D. A., Mesiano, S., Barker, N. M., Hurd, W. W., & Caplan, A. I. (2012). Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem J, 443(2), 361–368. https://doi.org/10.1042/BJ20111996
Carrino, David A., Sam Mesiano, Nichole M. Barker, William W. Hurd, and Arnold I. Caplan. “Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition.Biochem J 443, no. 2 (April 15, 2012): 361–68. https://doi.org/10.1042/BJ20111996.
Carrino DA, Mesiano S, Barker NM, Hurd WW, Caplan AI. Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem J. 2012 Apr 15;443(2):361–8.
Carrino, David A., et al. “Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition.Biochem J, vol. 443, no. 2, Apr. 2012, pp. 361–68. Pubmed, doi:10.1042/BJ20111996.
Carrino DA, Mesiano S, Barker NM, Hurd WW, Caplan AI. Proteoglycans of uterine fibroids and keloid scars: similarity in their proteoglycan composition. Biochem J. 2012 Apr 15;443(2):361–368.

Published In

Biochem J

DOI

EISSN

1470-8728

Publication Date

April 15, 2012

Volume

443

Issue

2

Start / End Page

361 / 368

Location

England

Related Subject Headings

  • Young Adult
  • Proteoglycans
  • Middle Aged
  • Leiomyoma
  • Keloid
  • Humans
  • Female
  • Extracellular Matrix
  • Biochemistry & Molecular Biology
  • Adult