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Differential regulation of myometrial prostaglandin production by changes in length.

Publication ,  Journal Article
Hurd, WW; Gibbs, SG; Rudinsky, KA
Published in: Am J Obstet Gynecol
February 2008

OBJECTIVE: The purpose of this study was to determine whether stretching and shortening of human myometrial strips alters prostaglandin production. STUDY DESIGN: We measured 6-keto prostaglandin F1alpha (PGF1alpha; a PGI2 metabolite) and PGF2alpha in the contraction baths of myometrial strips that were obtained at cesarean delivery from 5 term pregnant women. Fluid was collected after the stretching and after the strip lengths were decreased by 4%, 6%, or 8%. Prostaglandin concentrations were measured in triplicate by competitive enzyme immunoassay and compared by Kruskal-Wallis tests. RESULTS: Stretching myometrial strips increased the production of 6-keto PGF1alpha by 31%, but not PGF2alpha. Shortening strips had little effect on 6-keto PGF1alpha production, but increased PGF2alpha production by 158%. CONCLUSION: Stretching myometrial strips from pregnant women increases synthesis of PGI2; shortening strips increases synthesis of PGF2alpha. Differential prostaglandin synthesis that is related to myometrial stretching and shortening could play a role in uterine quiescence during gestation and increased contractility during parturition.

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Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

February 2008

Volume

198

Issue

2

Start / End Page

225.e1 / 225.e4

Location

United States

Related Subject Headings

  • Uterine Contraction
  • Pregnancy Trimester, Third
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Humans
  • Female
  • Biomechanical Phenomena
  • Adult
  • 6-Ketoprostaglandin F1 alpha
 

Citation

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Hurd, W. W., Gibbs, S. G., & Rudinsky, K. A. (2008). Differential regulation of myometrial prostaglandin production by changes in length. Am J Obstet Gynecol, 198(2), 225.e1-225.e4. https://doi.org/10.1016/j.ajog.2007.07.021
Hurd, William W., Shawn G. Gibbs, and Kari A. Rudinsky. “Differential regulation of myometrial prostaglandin production by changes in length.Am J Obstet Gynecol 198, no. 2 (February 2008): 225.e1-225.e4. https://doi.org/10.1016/j.ajog.2007.07.021.
Hurd WW, Gibbs SG, Rudinsky KA. Differential regulation of myometrial prostaglandin production by changes in length. Am J Obstet Gynecol. 2008 Feb;198(2):225.e1-225.e4.
Hurd, William W., et al. “Differential regulation of myometrial prostaglandin production by changes in length.Am J Obstet Gynecol, vol. 198, no. 2, Feb. 2008, pp. 225.e1-225.e4. Pubmed, doi:10.1016/j.ajog.2007.07.021.
Hurd WW, Gibbs SG, Rudinsky KA. Differential regulation of myometrial prostaglandin production by changes in length. Am J Obstet Gynecol. 2008 Feb;198(2):225.e1-225.e4.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

February 2008

Volume

198

Issue

2

Start / End Page

225.e1 / 225.e4

Location

United States

Related Subject Headings

  • Uterine Contraction
  • Pregnancy Trimester, Third
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Myometrium
  • Humans
  • Female
  • Biomechanical Phenomena
  • Adult
  • 6-Ketoprostaglandin F1 alpha