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Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy.

Publication ,  Journal Article
Lopez Guerra, JL; Wei, Q; Yuan, X; Gomez, D; Liu, Z; Zhuang, Y; Yin, M; Li, M; Wang, L-E; Cox, JD; Liao, Z
Published in: Radiother Oncol
November 2011

PURPOSE: We investigated the association between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and the risk of radiation-induced esophageal toxicity (RIET) in patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHODS: The experimental dataset comprised 120 NSCLC patients who were treated with radio(chemo)therapy between 2005 and 2009, when novel radiation techniques were implemented at MD Anderson. The validation dataset comprised 181 NSCLC patients treated between 1998 and 2004. We genotyped two SNPs of the HSPB1 gene (rs2868370 and rs2868371) by TaqMan assay. RESULTS: Univariate and multivariate analyses of the experimental dataset showed that the CG/GG genotypes of HSPB1 rs2868371 were associated with significantly lower risk of grade ⩾3 RIET than the CC genotype (univariate hazard ratio [HR] 0.30; 95% confidence interval [CI], 0.10-0.91; P=0.033; multivariate HR 0.29; 95% CI, 0.09-0.97; P=0.045). This difference in risk was replicated in the validation cohort despite the different radiation techniques used during that period. CONCLUSIONS: The CG/GG genotypes of HSPB1 rs2868371 were associated with lower risk of RIET, compared with the CC genotype in patients with NSCLC treated with radio(chemo)therapy. This finding should be validated in large multi-institutional prospective trials.

Duke Scholars

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Published In

Radiother Oncol

DOI

EISSN

1879-0887

Publication Date

November 2011

Volume

101

Issue

2

Start / End Page

271 / 277

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Molecular Chaperones
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Heat-Shock Proteins
  • HSP27 Heat-Shock Proteins
 

Citation

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Lopez Guerra, J. L., Wei, Q., Yuan, X., Gomez, D., Liu, Z., Zhuang, Y., … Liao, Z. (2011). Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy. Radiother Oncol, 101(2), 271–277. https://doi.org/10.1016/j.radonc.2011.08.039
Lopez Guerra, Jose Luis, Qingyi Wei, Xianglin Yuan, Daniel Gomez, Zhensheng Liu, Yan Zhuang, Ming Yin, et al. “Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy.Radiother Oncol 101, no. 2 (November 2011): 271–77. https://doi.org/10.1016/j.radonc.2011.08.039.
Lopez Guerra, Jose Luis, et al. “Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy.Radiother Oncol, vol. 101, no. 2, Nov. 2011, pp. 271–77. Pubmed, doi:10.1016/j.radonc.2011.08.039.
Lopez Guerra JL, Wei Q, Yuan X, Gomez D, Liu Z, Zhuang Y, Yin M, Li M, Wang L-E, Cox JD, Liao Z. Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy. Radiother Oncol. 2011 Nov;101(2):271–277.
Journal cover image

Published In

Radiother Oncol

DOI

EISSN

1879-0887

Publication Date

November 2011

Volume

101

Issue

2

Start / End Page

271 / 277

Location

Ireland

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Molecular Chaperones
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Heat-Shock Proteins
  • HSP27 Heat-Shock Proteins