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Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study.

Publication ,  Journal Article
Li, C; Liu, Z; Wang, LE; Gershenwald, JE; Lee, JE; Prieto, VG; Duvic, M; Grimm, EA; Wei, Q
Published in: Int J Cancer
May 1, 2008

In a hospital-based case-control study of 805 non-Hispanic whites with cutaneous melanoma and 841 cancer-free age-, sex- and ethnicity-matched control subjects, 3 VDR polymorphisms (i.e., TaqI, BsmI and FokI) were genotyped using blood samples collected between 1994 and 2006. We tested the hypothesis that the haplotypes and combined genotypes of these polymorphisms were associated with melanoma risk by interacting with known risk factors. Haplotypes t-B-F (adjusted odds ratio [OR], 0.52; 95% confidence interval [CI], 0.34-0.80) and t-B-f (adjusted OR, 0.51; CI, 0.27-0.94) were associated with a reduced risk when compared to T-b-f. The combined genotypes Tt+tt/Bb+BB/Ff+ff (adjusted OR, 0.69; CI, 0.52, 0.90) and Tt+tt/Bb+BB/FF (adjusted OR, 0.58; CI, 0.43, 0.78) were also associated with reduced risk, whereas the combined genotype TT/Bb+BB/Ff+ff genotype (adjusted OR, 2.35; CI, 1.13, 4.98) was associated with increased risk when compared to TT/bb/Ff+ff genotypes. On multivariate analysis, only the TaqI polymorphism was an independent risk factor, while the FokI polymorphism interacted with skin color (p = 0.029), moles (p = 0.017) and first-degree relatives with any cancer (p = 0.013) in modifying risk. Together, these findings suggest that VDR polymorphisms may directly affect or modify the risk associated with known melanoma risk factors. Larger, population-based studies are needed to replicate our findings.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

May 1, 2008

Volume

122

Issue

9

Start / End Page

2077 / 2084

Location

United States

Related Subject Headings

  • White People
  • Texas
  • Skin Neoplasms
  • Risk Factors
  • Risk Assessment
  • Research Design
  • Receptors, Calcitriol
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Odds Ratio
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, C., Liu, Z., Wang, L. E., Gershenwald, J. E., Lee, J. E., Prieto, V. G., … Wei, Q. (2008). Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study. Int J Cancer, 122(9), 2077–2084. https://doi.org/10.1002/ijc.23357
Li, Chunying, Zhensheng Liu, Li E. Wang, Jeffrey E. Gershenwald, Jeffrey E. Lee, Victor G. Prieto, Madeleine Duvic, Elizabeth A. Grimm, and Qingyi Wei. “Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study.Int J Cancer 122, no. 9 (May 1, 2008): 2077–84. https://doi.org/10.1002/ijc.23357.
Li C, Liu Z, Wang LE, Gershenwald JE, Lee JE, Prieto VG, et al. Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study. Int J Cancer. 2008 May 1;122(9):2077–84.
Li, Chunying, et al. “Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study.Int J Cancer, vol. 122, no. 9, May 2008, pp. 2077–84. Pubmed, doi:10.1002/ijc.23357.
Li C, Liu Z, Wang LE, Gershenwald JE, Lee JE, Prieto VG, Duvic M, Grimm EA, Wei Q. Haplotype and genotypes of the VDR gene and cutaneous melanoma risk in non-Hispanic whites in Texas: a case-control study. Int J Cancer. 2008 May 1;122(9):2077–2084.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

May 1, 2008

Volume

122

Issue

9

Start / End Page

2077 / 2084

Location

United States

Related Subject Headings

  • White People
  • Texas
  • Skin Neoplasms
  • Risk Factors
  • Risk Assessment
  • Research Design
  • Receptors, Calcitriol
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Odds Ratio