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Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.

Publication ,  Journal Article
Li, C; Hu, Z; Liu, Z; Wang, L-E; Gershenwald, JE; Lee, JE; Prieto, VG; Duvic, M; Grimm, EA; Wei, Q
Published in: Cancer
April 15, 2007

BACKGROUND: Nitric oxide (NO) is a multifunctional molecule that is produced by both neuronal NO synthase (nNOS) and inducible NO synthase (iNOS), and the expression of nNOS and iNOS is up-regulated in various cancer cells, including cutaneous melanoma (CM). The authors hypothesized that selected functional single-nucleotide polymorphisms (SNPs) in the nNOS and iNOS genes are associated with the risk of CM. METHODS: In a hospital-based case-control study of 602 non-Hispanic white patients with CM and 603 matched, cancer-free controls, the authors genotyped the nNOS -84 guanine-to-adenine (G-->A), nNOS 276 cytosine-to-thymine (C-->T), iNOS Ex16+14C-->T, and iNOS 974G-->T SNPs and assessed their associations with the risk of CM in multivariate logistic regression models. RESULTS: A significantly increased risk of CM was associated with the nNOS -84G-->A (adjusted odds ratio [OR], 1.49; 95% confidence interval [95% CI], 1.05-2.13) and -84AG+AA (OR, 1.48; 95% CI, 1.06-2.06) genotypes compared with the nNOS -84GG genotype, but not with other nNOS or iNOS SNPs. In a combined analysis, an increased risk of CM was associated with the nNOS -84AA+AG/276CT+TT genotype (OR, 1.70; 95% CI, 1.05-2.76) and the nNOS -84AA+AG/276CC genotype (OR, 1.70; 95% CI, 1.08-2.68) compared with the nNOS -84GG/276CT+TT genotypes. No altered risk of CM was associated with iNOS genotypes. In addition, there was statistical evidence of interaction of nNOS SNPs with having moles (P = .002) and sunburns (P = .017). CONCLUSIONS: Genetic variants of nNOS, but not iNOS, may be biomarkers for susceptibility to CM, and the risk of CM associated with sunburns and moles may be modulated by nNOS variant genotypes.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 15, 2007

Volume

109

Issue

8

Start / End Page

1570 / 1578

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Risk Factors
  • Reverse Transcriptase Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase Type I
  • Melanoma
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Li, C., Hu, Z., Liu, Z., Wang, L.-E., Gershenwald, J. E., Lee, J. E., … Wei, Q. (2007). Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study. Cancer, 109(8), 1570–1578. https://doi.org/10.1002/cncr.22582
Li, Chunying, Zhibin Hu, Zhensheng Liu, Li-E Wang, Jeffrey E. Gershenwald, Jeffrey E. Lee, Victor G. Prieto, Madeleine Duvic, Elizabeth A. Grimm, and Qingyi Wei. “Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.Cancer 109, no. 8 (April 15, 2007): 1570–78. https://doi.org/10.1002/cncr.22582.
Li C, Hu Z, Liu Z, Wang L-E, Gershenwald JE, Lee JE, et al. Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study. Cancer. 2007 Apr 15;109(8):1570–8.
Li, Chunying, et al. “Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.Cancer, vol. 109, no. 8, Apr. 2007, pp. 1570–78. Pubmed, doi:10.1002/cncr.22582.
Li C, Hu Z, Liu Z, Wang L-E, Gershenwald JE, Lee JE, Prieto VG, Duvic M, Grimm EA, Wei Q. Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study. Cancer. 2007 Apr 15;109(8):1570–1578.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

April 15, 2007

Volume

109

Issue

8

Start / End Page

1570 / 1578

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Risk Factors
  • Reverse Transcriptase Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase Type I
  • Melanoma
  • Male
  • Humans