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Loss of uteroglobin expression in prostate cancer: relationship to advancing grade.

Publication ,  Journal Article
Weeraratna, AT; Cajigas, JA; Schwartz, A; Enquist, EG; Manyak, MJ; Patierno, SR
Published in: Clin Cancer Res
December 1997

We have shown previously that the secretory protein uteroglobin (UG) is highly expressed in normal human prostate tissue but this expression is either lost or altered in human prostate cancer cell lines. Treatment of these cell lines with recombinant human UG inhibits their ability to invade human reconstituted basement membrane by up to 90%, implying that the loss of normal UG expression may be related to the invasive potential of prostate cancer. Because invasion represents a critical step in metastasis, the expression patterns of UG could provide a unique and relevant indicator of cancer progression. In this study, we present the immunohistochemical analyses of fresh frozen prostate tissues from surgical specimens taken from 50 patients. Eight slides per patient were analyzed for UG staining. Slides from 26 patients showed evidence of prostate cancer, whereas slides from the remaining 24 patients showed only benign glands. The results demonstrate UG immunoreactivity in normal prostate, benign prostatic hyperplasia, and prostatic atrophy; low but clearly positive expression in prostatic intraepithelial neoplasia; positive expression in cancerous glands of Gleason's pattern

Duke Scholars

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

December 1997

Volume

3

Issue

12 Pt 1

Start / End Page

2295 / 2300

Location

United States

Related Subject Headings

  • Uteroglobin
  • Urinary Bladder Neoplasms
  • Prostatic Neoplasms
  • Prostatic Hyperplasia
  • Prostatectomy
  • Prostate
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Immunohistochemistry
 

Citation

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Weeraratna, A. T., Cajigas, J. A., Schwartz, A., Enquist, E. G., Manyak, M. J., & Patierno, S. R. (1997). Loss of uteroglobin expression in prostate cancer: relationship to advancing grade. Clin Cancer Res, 3(12 Pt 1), 2295–2300.
Weeraratna, A. T., J. A. Cajigas, A. Schwartz, E. G. Enquist, M. J. Manyak, and S. R. Patierno. “Loss of uteroglobin expression in prostate cancer: relationship to advancing grade.Clin Cancer Res 3, no. 12 Pt 1 (December 1997): 2295–2300.
Weeraratna AT, Cajigas JA, Schwartz A, Enquist EG, Manyak MJ, Patierno SR. Loss of uteroglobin expression in prostate cancer: relationship to advancing grade. Clin Cancer Res. 1997 Dec;3(12 Pt 1):2295–300.
Weeraratna, A. T., et al. “Loss of uteroglobin expression in prostate cancer: relationship to advancing grade.Clin Cancer Res, vol. 3, no. 12 Pt 1, Dec. 1997, pp. 2295–300.
Weeraratna AT, Cajigas JA, Schwartz A, Enquist EG, Manyak MJ, Patierno SR. Loss of uteroglobin expression in prostate cancer: relationship to advancing grade. Clin Cancer Res. 1997 Dec;3(12 Pt 1):2295–2300.

Published In

Clin Cancer Res

ISSN

1078-0432

Publication Date

December 1997

Volume

3

Issue

12 Pt 1

Start / End Page

2295 / 2300

Location

United States

Related Subject Headings

  • Uteroglobin
  • Urinary Bladder Neoplasms
  • Prostatic Neoplasms
  • Prostatic Hyperplasia
  • Prostatectomy
  • Prostate
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Immunohistochemistry