Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing.
Publication
, Journal Article
Clark, RAF; Pavlis, M
Published in: J Invest Dermatol
March 2009
Either heredity mutations or adverse microenvironment conditions may result in dysregulation of the mammalian target of the rapamycin (mTOR) pathway. The former lead to clinical syndromes such as tuberous sclerosis, Peutz-Jeghers syndrome, and Cowden's disease, which are characterized by hamartomatous growth or cancer. The latter can be associated with poor wound healing as described by Goren et al. (2009, this issue).
Duke Scholars
Published In
J Invest Dermatol
DOI
EISSN
1523-1747
Publication Date
March 2009
Volume
129
Issue
3
Start / End Page
529 / 531
Location
United States
Related Subject Headings
- Wound Healing
- Tumor Suppressor Proteins
- Tuberous Sclerosis Complex 2 Protein
- Tuberous Sclerosis Complex 1 Protein
- Tuberous Sclerosis
- TOR Serine-Threonine Kinases
- Protein Kinases
- Phosphatidylinositol 3-Kinases
- Peutz-Jeghers Syndrome
- Neovascularization, Pathologic
Citation
APA
Chicago
ICMJE
MLA
NLM
Clark, R. A. F., & Pavlis, M. (2009). Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. J Invest Dermatol, 129(3), 529–531. https://doi.org/10.1038/jid.2008.441
Clark, Richard A. F., and Michelle Pavlis. “Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing.” J Invest Dermatol 129, no. 3 (March 2009): 529–31. https://doi.org/10.1038/jid.2008.441.
Clark RAF, Pavlis M. Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. J Invest Dermatol. 2009 Mar;129(3):529–31.
Clark, Richard A. F., and Michelle Pavlis. “Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing.” J Invest Dermatol, vol. 129, no. 3, Mar. 2009, pp. 529–31. Pubmed, doi:10.1038/jid.2008.441.
Clark RAF, Pavlis M. Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. J Invest Dermatol. 2009 Mar;129(3):529–531.
Published In
J Invest Dermatol
DOI
EISSN
1523-1747
Publication Date
March 2009
Volume
129
Issue
3
Start / End Page
529 / 531
Location
United States
Related Subject Headings
- Wound Healing
- Tumor Suppressor Proteins
- Tuberous Sclerosis Complex 2 Protein
- Tuberous Sclerosis Complex 1 Protein
- Tuberous Sclerosis
- TOR Serine-Threonine Kinases
- Protein Kinases
- Phosphatidylinositol 3-Kinases
- Peutz-Jeghers Syndrome
- Neovascularization, Pathologic