Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.
Publication
, Journal Article
Van Mater, D; Kolligs, FT; Dlugosz, AA; Fearon, ER
Published in: Genes Dev
May 15, 2003
Wnts have key roles in many developmental processes, including hair follicle growth and differentiation. Stabilization of beta-catenin is essential in the canonical Wnt signaling pathway. We developed transgenic mice expressing a regulated form of beta-catenin in the skin. Chronic activation of beta-catenin in resting (telogen) hair follicles resulted in changes consistent with induction of an exaggerated, aberrant growth phase (anagen). Transient activation of beta-catenin produced a normal anagen. Our data lend strong support to the notion that a Wnt/beta-catenin signal operating on hair follicle precursor cells serves as a crucial proximal signal for the telogen-anagen transition.
Duke Scholars
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Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
May 15, 2003
Volume
17
Issue
10
Start / End Page
1219 / 1224
Location
United States
Related Subject Headings
- beta Catenin
- Trans-Activators
- Signal Transduction
- Mice, Transgenic
- Mice
- Keratinocytes
- Hair Follicle
- Hair
- Epithelium
- Developmental Biology
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Chicago
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NLM
Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R. (2003). Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev, 17(10), 1219–1224. https://doi.org/10.1101/gad.1076103
Van Mater, David, Frank T. Kolligs, Andrzej A. Dlugosz, and Eric R. Fearon. “Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.” Genes Dev 17, no. 10 (May 15, 2003): 1219–24. https://doi.org/10.1101/gad.1076103.
Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER. Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev. 2003 May 15;17(10):1219–24.
Van Mater, David, et al. “Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice.” Genes Dev, vol. 17, no. 10, May 2003, pp. 1219–24. Pubmed, doi:10.1101/gad.1076103.
Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER. Transient activation of beta -catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes Dev. 2003 May 15;17(10):1219–1224.
Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
May 15, 2003
Volume
17
Issue
10
Start / End Page
1219 / 1224
Location
United States
Related Subject Headings
- beta Catenin
- Trans-Activators
- Signal Transduction
- Mice, Transgenic
- Mice
- Keratinocytes
- Hair Follicle
- Hair
- Epithelium
- Developmental Biology