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Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration.

Publication ,  Journal Article
Aghajanian, A; Wittchen, ES; Allingham, MJ; Garrett, TA; Burridge, K
Published in: J Thromb Haemost
September 2008

The endothelial lining of the vasculature forms the physical barrier between the blood and underlying tissues. Junctions between adjacent endothelial cells are dynamically modulated to sustain vascular homeostasis and to support the transendothelial migration of leukocytes during inflammation. A variety of factors initiate intracellular signaling pathways that regulate the opening and resealing of junctional complexes. This review focuses on three primary signaling pathways initiated within endothelial cells by the binding of vasoactive factors and leukocyte adhesion: Rho GTPases, reactive oxygen species, and tyrosine phosphorylation of junctional proteins. These pathways converge to regulate junctional permeability, either by affecting the stability of junctional proteins or by modulating their interactions. Although much progress has been made in understanding the relationships of these pathways, many questions remain to be answered. A full understanding of the signaling cascades that affect endothelial junctions should identify novel therapeutic targets for diseases that involve excessive permeability or inappropriate leukocyte infiltration into tissues.

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Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

September 2008

Volume

6

Issue

9

Start / End Page

1453 / 1460

Location

England

Related Subject Headings

  • Tyrosine
  • Phosphorylation
  • Muscle Proteins
  • Intercellular Junctions
  • Humans
  • Endothelium, Vascular
  • Chemotaxis, Leukocyte
  • Cardiovascular System & Hematology
  • Capillary Permeability
  • 3202 Clinical sciences
 

Citation

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Aghajanian, A., Wittchen, E. S., Allingham, M. J., Garrett, T. A., & Burridge, K. (2008). Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J Thromb Haemost, 6(9), 1453–1460. https://doi.org/10.1111/j.1538-7836.2008.03087.x
Aghajanian, A., E. S. Wittchen, M. J. Allingham, T. A. Garrett, and K. Burridge. “Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration.J Thromb Haemost 6, no. 9 (September 2008): 1453–60. https://doi.org/10.1111/j.1538-7836.2008.03087.x.
Aghajanian A, Wittchen ES, Allingham MJ, Garrett TA, Burridge K. Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J Thromb Haemost. 2008 Sep;6(9):1453–60.
Aghajanian, A., et al. “Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration.J Thromb Haemost, vol. 6, no. 9, Sept. 2008, pp. 1453–60. Pubmed, doi:10.1111/j.1538-7836.2008.03087.x.
Aghajanian A, Wittchen ES, Allingham MJ, Garrett TA, Burridge K. Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J Thromb Haemost. 2008 Sep;6(9):1453–1460.
Journal cover image

Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

September 2008

Volume

6

Issue

9

Start / End Page

1453 / 1460

Location

England

Related Subject Headings

  • Tyrosine
  • Phosphorylation
  • Muscle Proteins
  • Intercellular Junctions
  • Humans
  • Endothelium, Vascular
  • Chemotaxis, Leukocyte
  • Cardiovascular System & Hematology
  • Capillary Permeability
  • 3202 Clinical sciences