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Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement.

Publication ,  Journal Article
McCall, CM; Shi, C; Klein, AP; Konukiewitz, B; Edil, BH; Ellison, TA; Wolfgang, CL; Schulick, RD; Klöppel, G; Hruban, RH
Published in: Hum Pathol
August 2012

Pancreatic neuroendocrine tumors with prominent stromal fibrosis are often clinically, radiographically, and grossly indistinguishable from ductal adenocarcinoma. We recently described a small series of fibrotic pancreatic neuroendocrine tumors that express serotonin. To understand better the relationship between histopathologic patterns and serotonin expression, we reviewed 361 pancreatic neuroendocrine tumors to identify those with prominent stromal fibrosis exceeding 30% of total tumor area. We identified 52 cases and immunolabeled these neoplasms with antibodies to serotonin and Ki-67. Two predominant histologic subtypes were identified: 14 (26.9%) of 52 had a trabecular or trabecular-glandular cellular pattern with interspersed fibrosis, whereas 38 (73.1%) of 52 had solid architecture. Of the 52, 14 (26.9%) pancreatic neuroendocrine tumors showed at least focal serotonin immunoreactivity. Tumors with predominantly trabecular architecture were significantly more likely to express serotonin than those with solid architecture (P < .01). Only 2 of 34 pancreatic neuroendocrine tumors with fibrosis less than 30% of total tumor area expressed serotonin. The 14 serotonin-expressing tumors were less likely to have lymph node metastases (P = .016) and more likely to involve large pancreatic ducts (P < .01) than were the 38 serotonin-negative tumors. The serotonin-expressing tumors were also found in a younger patient population (P < .01). There was no significant association of serotonin immunoreactivity with Ki-67 proliferation index, tumor size, or distant metastases. Our data demonstrate a strong correlation between trabecular architecture and serotonin immunoreactivity in pancreatic neuroendocrine tumors with stromal fibrosis. Serotonin-expressing tumors are also less likely to have lymph node metastases and more likely to involve large pancreatic ducts.

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Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

August 2012

Volume

43

Issue

8

Start / End Page

1169 / 1176

Location

United States

Related Subject Headings

  • Serotonin
  • Retrospective Studies
  • Pathology
  • Pancreatic Neoplasms
  • Pancreatic Ducts
  • Neuroendocrine Tumors
  • Middle Aged
  • Male
  • Humans
  • Fibrosis
 

Citation

APA
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McCall, C. M., Shi, C., Klein, A. P., Konukiewitz, B., Edil, B. H., Ellison, T. A., … Hruban, R. H. (2012). Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum Pathol, 43(8), 1169–1176. https://doi.org/10.1016/j.humpath.2011.09.014
McCall, Chad M., Chanjuan Shi, Alison P. Klein, Björn Konukiewitz, Barish H. Edil, Trevor A. Ellison, Christopher L. Wolfgang, Richard D. Schulick, Günter Klöppel, and Ralph H. Hruban. “Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement.Hum Pathol 43, no. 8 (August 2012): 1169–76. https://doi.org/10.1016/j.humpath.2011.09.014.
McCall CM, Shi C, Klein AP, Konukiewitz B, Edil BH, Ellison TA, et al. Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum Pathol. 2012 Aug;43(8):1169–76.
McCall, Chad M., et al. “Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement.Hum Pathol, vol. 43, no. 8, Aug. 2012, pp. 1169–76. Pubmed, doi:10.1016/j.humpath.2011.09.014.
McCall CM, Shi C, Klein AP, Konukiewitz B, Edil BH, Ellison TA, Wolfgang CL, Schulick RD, Klöppel G, Hruban RH. Serotonin expression in pancreatic neuroendocrine tumors correlates with a trabecular histologic pattern and large duct involvement. Hum Pathol. 2012 Aug;43(8):1169–1176.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

August 2012

Volume

43

Issue

8

Start / End Page

1169 / 1176

Location

United States

Related Subject Headings

  • Serotonin
  • Retrospective Studies
  • Pathology
  • Pancreatic Neoplasms
  • Pancreatic Ducts
  • Neuroendocrine Tumors
  • Middle Aged
  • Male
  • Humans
  • Fibrosis