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Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy.

Publication ,  Journal Article
Guadalupe, M; Pollock, BH; Westbrook, S; Redding, S; Bullock, D; Anstead, G; Agan, BK; Marconi, VC; Barbieri, S; Sankar, V; Rebeles, J; Lei, X ...
Published in: J Acquir Immune Defic Syndr
January 1, 2011

BACKGROUND: Kaposi's sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposi's sarcoma. METHODS: We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients. RESULTS: Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm3 less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm3 less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm3 less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics. CONCLUSIONS: Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposi's sarcoma predictors.

Duke Scholars

Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

January 1, 2011

Volume

56

Issue

1

Start / End Page

83 / 90

Location

United States

Related Subject Headings

  • Virus Latency
  • Virology
  • Viral Load
  • Sarcoma, Kaposi
  • Risk Factors
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Herpesvirus 8, Human
 

Citation

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Chicago
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Guadalupe, M., Pollock, B. H., Westbrook, S., Redding, S., Bullock, D., Anstead, G., … Gao, S.-J. (2011). Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy. J Acquir Immune Defic Syndr, 56(1), 83–90. https://doi.org/10.1097/QAI.0b013e3181fdc928
Guadalupe, Moraima, Brad H. Pollock, Steven Westbrook, Spencer Redding, Delia Bullock, Gregory Anstead, Brian K. Agan, et al. “Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy.J Acquir Immune Defic Syndr 56, no. 1 (January 1, 2011): 83–90. https://doi.org/10.1097/QAI.0b013e3181fdc928.
Guadalupe M, Pollock BH, Westbrook S, Redding S, Bullock D, Anstead G, et al. Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy. J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):83–90.
Guadalupe, Moraima, et al. “Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy.J Acquir Immune Defic Syndr, vol. 56, no. 1, Jan. 2011, pp. 83–90. Pubmed, doi:10.1097/QAI.0b013e3181fdc928.
Guadalupe M, Pollock BH, Westbrook S, Redding S, Bullock D, Anstead G, Agan BK, Marconi VC, Barbieri S, Sankar V, Rebeles J, Flahive Y, Schoolfield J, Wang L, Lei X, Dow D, Yeh C-K, Dang H, Infante AJ, Gao S-J. Risk factors influencing antibody responses to Kaposi's sarcoma-associated herpesvirus latent and lytic antigens in patients under antiretroviral therapy. J Acquir Immune Defic Syndr. 2011 Jan 1;56(1):83–90.

Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

January 1, 2011

Volume

56

Issue

1

Start / End Page

83 / 90

Location

United States

Related Subject Headings

  • Virus Latency
  • Virology
  • Viral Load
  • Sarcoma, Kaposi
  • Risk Factors
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Humans
  • Herpesvirus 8, Human